Endopleura uchi (Huber) Cuatrec.: A medicinal plant for gynecological treatments – Reproductive toxicity assessment in zebrafish (Danio rerio)

ConclusionBased on the results, the EEu caused no adverse effects in the progenitors in both treatments (immersion and oral). However, it was observed that the concentrations 1.2, 2.5, and 5 mg/L (immersion), and the dose 500 mg/kg (oral) caused malformations in the offspring (F1 generation). These results emphasize the need for attention when using preparations from E. uchi, mainly for pregnant women. Further studies will be needed to compare its effects with the extract's major compound (bergenin).Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research