Morphological variability in unrepaired bilateral clefts with and without cleft palate evaluated with geometric morphometrics.

Morphological variability in unrepaired bilateral clefts with and without cleft palate evaluated with geometric morphometrics. J Anat. 2019 Dec 02;: Authors: Latif A, Kuijpers MAR, Rachwalski M, Latief BS, Kuijpers-Jagtman AM, Fudalej PS Abstract In subjects with orofacial clefts, there is an unresolved controversy on the effect of congenital maxillary growth deficiency vs. the effect of surgical intervention on the outcome of treatment. Intrinsic growth impairment in subjects with orofacial clefts can be studied by comparing facial morphology of subjects with untreated cleft and unaffected individuals of the same ethnic background. Bilateral cleft lip and palate is the most severe and least prevalent form of the orofacial cleft. The aim of this study was to compare facial morphology in subjects with unrepaired complete bilateral clefts and unaffected controls using geometric morphometrics. Lateral cephalograms of 39 Indonesian subjects with unrepaired bilateral complete cleft lip and alveolus (mean age: 24 years), or unrepaired bilateral complete cleft lip, alveolus, and palate (mean age: 20.6 years) and 50 age and ethnically matched controls without a cleft (25 males, 25 females, mean age: 21.2 years) were digitized and traced and shape variability was explored using principal component analysis, while differences between groups and genders were evaluated with canonical variate analysis. Individuals with clefts had a more pronou...
Source: Journal of Anatomy - Category: Anatomy Authors: Tags: J Anat Source Type: research