Mechanism of acupuncture on anti-neuronal apoptosis and the regulation of PI3K/AKT signaling pathway in heroin relapse rats

Publication date: Available online 4 December 2019Source: World Journal of Acupuncture - MoxibustionAuthor(s): Xiao-rong HOU, Xing-hui CAI, Sheng-bing WU, Rong-jun ZHANG, Li-da ZHANG, Xiao-ge SONGAbstractObjectiveTo explore the mechanism of acupuncture intervention on anti-neuronal apoptosis in heroin-dependent rats based on the PI3K/AKT signaling pathway.MethodsA total of 30 SD rats were randomly divided into a normal group, a model group and an acupuncture group, 10 rats in each one. In the model group and the acupuncture group, the heroin relapse rat model was established by intramuscular incremental injection of heroin. In the model group, no any intervention was applied. In the acupuncture group, after modeling, acupuncture was applied at “Băihuì (百会GV20)” and “Dàzhuī (大椎GV14)”. Transmission electron microscope (TEM) was adopted to observe neuronal apoptosis in the rats. The effect of acupuncture on anti-neuronal apoptosis was compared. Using reverse transcription-polymerase chain reaction (RT-PCR) and western blot methods, the mRNA and protein expressions of PI3K and AKT were detected in ventral tegmental area (VTA).ResultsIt was found that edema was presented in VTA neuronal cytoplasm and organelles basically disappeared in the heroin relapse rats, nuclear chromatin aggregation, condensation and increased neuronal apoptosis were presented as well. After acupuncture at “Băihuì (百会GV20)” and “D...
Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research

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