Effects of synbiotic supplementation on the pulmonary manifestations and anthropometric measurements in children with cystic fibrosis- a randomized clinical trial

ConclusionsThe synbiotic had no significant effect on pulmonary and anthropometric outcomes in children with CF. Further studies are necessary to confirm these findings.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research

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AbstractPurpose of ReviewThe understanding of the human microbiome, especially of the oral cavity, has expanded exponentially since the advent of 16 rRNA PCR gene sequencing. Since the respiratory tract starts from the oral cavity and ends in the lung, study of the relationship between the oral microbiota and the lungs will allow us to understand the changes in lung disease compared with healthy state.Recent FindingsThe oral and lung microbiota were found to be similar, but the oral microbiota had greater diversity. The oral cavity especially the dorsal tongue was found to be a reservoir for bacteria causing pneumonia and ...
Source: Current Oral Health Reports - Category: Dentistry Source Type: research
What makes the Antabio ’s molecule candidate so unique is that it’s not an antibiotic. Antibiotics typically work by killing bacteria, whereas this molecule aims to disable the bacteria, making it less able to attack and inflame the lungs.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
THE MOTHER of stricken 13-year-old Ayden Cochrane last night made a desperate appeal for drugs bosses to save her son ’s life by giving him access to a wonder pill.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
The 2013 update of the Infection Prevention and Control (IP&C) Guideline outlined recommendations to prevent the spread of CF respiratory pathogens. We aimed to investigate the current infection control practi...
Source: BMC Pulmonary Medicine - Category: Respiratory Medicine Authors: Tags: Research article Source Type: research
A 51-year-old Caucasian male with cystic fibrosis (CF) (homozygous ΔF508) and mild obstructive lung disease (baseline forced expiratory volume in 1 second (FEV1) was 2.59L, 70% predicted), presented to our clinic with a history of recurrent fevers, cough with purulent sputum, and dyspnea on exertion. Comorbidities included chronic infection with Pseudomonas aerugi nosa, intermittent colonization with Exophiala dermatitidis, pancreatic insufficiency, adenomatous colon polyps (resected), osteopenia and CF-related diabetes.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Source Type: research
CONCLUSIONS: We found only one very small randomised controlled trial; this is not enough to make any reliable conclusion to support the use of blood transfusion. Whilst there appears to be some indication that chronic blood transfusion may play a roll in reducing the incidence of acute chest syndrome in people with sickle cell disease and albeit offering transfusions may be a widely accepted clinical practice, there is currently no reliable evidence to support or refute the perceived benefits of these as treatment options; very limited information about any of the potential harms associated with these interventions or ind...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Similar to patients with cystic fibrosis (CF) and non-CF bronchiectasis, patients with primary ciliary dyskinesia (PCD) are prone to recurrent or chronic lung infections with Pseudomonas aeruginosa. Chronic P. aeruginosa lung infection has a prevalence of up to 39% in patients with PCD [1] and is associated with structural damage, affecting lung function. Treatment of P. aeruginosa infection is challenging because P. aeruginosa adapts to the host environment through genotypic/phenotypic changes, promoting a reduced immune response [2].
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research
Source: ScienceNOW - Category: Science Authors: Tags: twil Source Type: news
Many bacteria produce and use extracellular signaling molecules such as acyl homoserine lactones (AHLs) to communicate and coordinate behavior in a cell-density dependent manner, via a communication system called quorum sensing (QS). This system regulates behaviors including but not limited to virulence and biofilm formation. We focused on Pseudomonas aeruginosa, a human opportunistic pathogen that is involved in acute and chronic lung infections and which disproportionately affects people with cystic fibrosis. P. aeruginosa infections are becoming increasingly challenging to treat with the spread of antibiotic resistance....
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Genetic Testing and Molecular Biomarkers,Volume 24, Issue 1, Page 24-32, January 2020.
Source: Genetic Testing and Molecular Biomarkers - Category: Genetics & Stem Cells Authors: Source Type: research
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