Hierarchical Bi2Zr2O7:Dy3+ architectures fabricated by bio-surfactant assisted hydrothermal route for anti-oxidant, anti-bacterial and anti-cancer activities

Publication date: 15 February 2020Source: Materials Chemistry and Physics, Volume 242Author(s): A.S. Rajashekharaiah, G.P. Darshan, H.B. Premkumar, P. Lalitha, S.C. Sharma, H. NagabhushanaAbstractNano biotechnology is rapidly growing eco-friendly research area and used in various broad sections, such as biology, chemistry, physics, biomedicine and material engineering. The synthesis of highly efficient, non-toxic, inexpensive and environmental friendly nanomaterial is an urgent need. The aim of the present work was assessment of anti-oxidant, anti-bacterial and cytotoxicity potentials of Bi2Zr2O7:Dy3+ (1–11 mol %) nanophosphors synthesized via hydrothermal route using Epigallocatechin Gallate as a bio-surfactant. The morphologies of the prepared samples can be significantly modified by altering various synthesis factors, namely hydrothermal reaction temperature, Epigallocatechin Gallate concentration, reaction time and pH level. 1, 1-Diphenyl-2-picrylhydrazyl was used in experiments to assess the anti-oxidant activity of prepared sample, which revealed an impressive prevention in comparison with positive control. Agar diffusion tests performed to examine the anti-bacterial potential against both gram-positive and negative Escherichia coli, Staphylococcus aureus, and Pseudomonas desmolyticum strains. The nanophosphor exhibit maximum viability against Pseudomonas desmolyticum (10.88 ± 0.31 mm/μL) for 1000 μg/μL. The highest cytotox...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research

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This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, researchers collected monocytes from the bone marrow of healthy mice and cultured them in conditions that transformed them into macrophages. The lab also developed vitamin-based nanoparticles that were especially good at delivering messenger RNA, molecules that translate genetic information into functional proteins. The scientists, who specialize in messenger RNA for therapeutic purposes, constructed a messenger RNA encoding an antimicrobial peptide and a signal protein. The signal protein enabled the specific accumulation of the antimicrobial peptide in internal macrophage structures called lysosomes...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
In this study, an analog of Magainin II was designed and produced as a recombinant fusion protein. The designed sequence contained 24 amino acid residues (P24), in which Lys, His, Ser residues were substituted with Arg and also, hydrophobic Phe was replaced with Trp. Recombinant production of P24 in Escherichia coli (E. coli) BL21 using pTYB21, containing chitin binding domain and intein sequence at the N-terminus of the peptide gene, resulted in 1μg mL-1 product from culture. Chitin column chromatography, followed by online peptide cleavage with thiol reducing agent was applied to purify the peptide. Antimicrobial acti...
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
In this study, a light phase oil was obtained by molecular distillation from cold-pressed grapefruit essential oil and GC-MS was used to identify its chemical composition. The antimicrobial activity of the light phase oil was tested by filter paper diffusion method, and the anticancer activity was determined by the Cell Counting Kit-8 (CCK-8) assay. Twenty-four components were detected with a total relative content of 99.74%, including 97.48% of terpenes and 1.66% of oxygenated terpenes. The light phase oil had the best antimicrobial effect on Bacillus subtilis, followed by Escherichia coli, Staphylococcus aureus and Salmo...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Noviany Noviany, Arash Samadi, Nita Yuliyan, Sutopo Hadi, Muhammad Aziz, Neny Purwitasari, Suriyati Mohamad, Nur Najihah Ismail, Kevin P. Gable, Taifo MahmudAbstractA new 2-arylbenzofuran, sesbagrandiflorain C (1), together with four known compounds, 2-(3,4-dihydroxy-2-methoxyphenyl)-4-hydroxy-6-methoxybenzofuran-3-carbaldehyde (2), 2-(4-hydroxy-2-methoxyphenyl)-5,6-dimethoxybenzofuran-3-carboxaldehyde (3), sesbagrandiflorain A (4) and sesbagrandiflorain B (5), have been isolated from the stem bark of an Indonesian plant, Sesbania grandiflor...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
Publication date: Available online 27 December 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Rajesh P. Shastry, R.R. Arunrenganathan, V. Ravishankar RaiAbstractEnterococcus faecalis is a common commensal of the gastrointestinal tract and produce different types of bacteriocins. Here, we describe En. faecalis strain from fresh water fish, which produce a bacteriocin significantly (p 
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Publication date: Available online 16 December 2019Source: European Polymer JournalAuthor(s): Roya Sedghi, Marziye Gholami, Alireza Shaabani, Mahyar Saber, Hassan NiknejadAbstractThe aim of this study was to prepare the new chitosan derivative nanofibers and evaluate their potential in the prevention of local breast cancer recurrence. In this work, the anticancer properties of nanofibers were increased and the side effects of using them were minimized. The chemical structure and morphology of the nanofibers were investigated by Fourier transform infrared spectroscopy (FT-IR), CHNS elemental analysis, X-ray diffraction (XRD...
Source: European Polymer Journal - Category: Chemistry Source Type: research
Six new dihydroisocoumarins, aspergimarins A−F (1−6), were discovered together with five known analogs (7−11) from a monoculture of the sponge-derived fungus Aspergillus sp. NBUF87. The structures of these compounds were elucidated through comprehensive spectroscopic methods, and absolute configurations were assigned after X-ray crystallography, use of the modified Mosher’s method, and comparison of electronic circular dichroism (ECD) data with literature values for previously reported analogs. Compounds 1−11 were evaluated in a variety of bioassays, and at 100 μM, both 1 and 5 showed signi...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: Available online 26 November 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Ayşenur Aygün, Fulya Gülbağça, Mehmet Salih Nas, Mehmet Hakkı Alma, Mehmet Harbi Çalımlı, Buket Ustaoglu, Yasemin Celik Altunoglu, Mehmet Cengiz Baloğlu, Kemal Cellat, Fatih ŞenAbstractThis paper reports the anticarcinogenic and antimicrobial properties of silver nanoparticles (Ag NPs) obtained by green synthesis using the extract of Rheum ribes (R. ribes), a medicinal plant. For the synthesis of Ag NPs, the ethanolic extracts of R. ribes were used as a reducing as well as th...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
This study highlights the investigation of the green fluorescence in NaTb(WO4)2 materials (NaTbW Bulk and NaTbW Nano) synthesized via template free hydrothermal method as a function of particle size and morphology. Herein, we demonstrated the biocompatibility and intracellular green fluorescence of NaTbW Nano samples using HeLa cells for cell imaging applications. Powder X-ray diffraction studies showed that the as synthesized NaTbW Bulk and NaTbW Nano crystallize in the Scheelite like tetragonal crystal system with the I41/a space group. The reaction pH and solvent is observed to play a critical role in determining partic...
Source: Biol Sci Space - Category: Science Authors: Tags: Mater Sci Eng C Mater Biol Appl Source Type: research
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