The Risk of Diabetes Mellitus in Patients with Juvenile Idiopathic Arthritis.

CONCLUSION: JIA appears to be associated with an increased risk of T1D compared to asthma and healthy children. PMID: 31787600 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research

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CONCLUSION:: Carpal tunnel release under platelet inhibition with acetylsalicylic acid is safe and can be performed without interruption of such medication. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. PMID: 31985640 [PubMed - in process]
Source: Hand Surgery - Category: Surgery Authors: Tags: Plast Reconstr Surg Source Type: research
Publication date: Available online 28 January 2020Source: Best Practice &Research Clinical RheumatologyAuthor(s): Ana M. Ortiz, Sebnem Ataman
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
Publication date: Available online 27 January 2020Source: Best Practice &Research Clinical RheumatologyAuthor(s): Peter C. Taylor, Shing T. LawAbstractThe outlook for people living with rheumatoid arthritis (RA) has improved tremendously in a generation. Major contributions to this include recognition of the importance of early treatment initiation, improved understanding of the pathobiology, the identification of therapeutic targets and their subsequent validation in clinic trials and the realisation of the importance of ‘tight control’ of inflammatory responses. Despite these advances, many patients meeti...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
Publication date: Available online 27 January 2020Source: Best Practice &Research Clinical RheumatologyAuthor(s): Lykke Midtbøll Ørnbjerg, Mikkel ØstergaardAbstractStructural damage progression in patients with established rheumatoid arthritis (RA) has traditionally been assessed by conventional radiography (CR), which has proven its value in clinical practice and clinical trials over the past decades. The most prominent abnormalities visualized by CR in RA patients are erosions as a consequence of bone destruction and joint space narrowing (JSN) as a consequence of cartilage damage. Several valida...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
Publication date: Available online 27 January 2020Source: Best Practice &Research Clinical RheumatologyAuthor(s): Serena Bugatti, Emanuele Bozzalla Cassione, Ludovico De Stefano, Antonio ManzoAbstractThe development of rheumatoid arthritis (RA), at least in its autoantibody-positive subset, evolves through a series of events starting well before the appearance of synovitis. The distinction between ‘early’ and ‘established’ RA is, therefore, an evolving concept. In routine practice, however, the management of RA still starts with the occurrence of clinically detectable synovitis. As such, the syn...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
Publication date: Available online 28 January 2020Source: Respiratory Medicine Case ReportsAuthor(s): Silvia De Rosa, Gianlorenzo Golino, Claudio RoncoAbstractStatus asthmaticus is a life-threatening disorder that can manifest in dangerous levels of hypercapnia and acidosis. The use of extracorporeal carbon dioxide removal (ECCO2R) has been used successfully to control pH and PaCO2 in patients with acute severe asthma. The present report describes the use of this technology in near-fatal asthma with brain death, and awaiting organ harvest.The ProLUNG® system consists of a veno-venous hemoperfusion circuit with an artif...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
In conclusion, the current study shed light on the potential neuroprotective role of metformin and trimetazidine in the amelioration of cognitive function via hindering inflammatory processes in diabetic epileptic rats.Graphical abstractDiagram illustrating alterations in the hippocampus induced in diabetic epileptic rats. DAP, death-associated protein; ATP/ADP, ratio of adenosine triphosphate and adenosine diphosphate; mTOR, mammalian target of rapamycin; Casp-3, caspase-3; TNF-α, tumor necrosis factor-α; IL-1β, interleukin-1β; NF-κB, nuclear factor-κB; IGF-1, insulin growth factor 1.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 28 January 2020Source: Journal of Biomedical InformaticsAuthor(s): Akhilesh Kumar Bajpai, Sravanthi Davuluri, Kriti Tiwary, Sithalechumi Narayanan, Sailaja Oguru, Kavyashree Basavaraju, Deena Dayalan, Kavitha Thirumurugan, Kshitish K. AcharyaAbstractIn absence of periodic systematic comparisons, biologists/bioinformaticians may be forced to make a subjective selection among the many protein-protein interaction (PPI) databases and tools. We conducted a comprehensive compilation and comparison of such resources. We compiled 375 PPI resources, short-listed 125 important ones (both lists are ...
Source: Journal of Biomedical Informatics - Category: Information Technology Source Type: research
Publication date: Available online 28 January 2020Source: Journal of Biomedical InformaticsAuthor(s): Sisi Ma, Pamela J. Schreiner, Elizabeth R. Seaquist, Mehmet Ugurbil, Rachel Zmora, Lisa S. ChowAbstractThe presence of missing data at the time of prediction limits the application of risk models in clinical and research settings. Common ways of handling missing data at the time of prediction include measuring the missing value and employing statistical methods. Measuring missing value incurs additional cost, whereas previously reported statistical methods results in reduced performance compared to when all variables are m...
Source: Journal of Biomedical Informatics - Category: Information Technology Source Type: research
Conclusions were roughly similar for children exposed to maternal clinical RA and for children only followed up to 16 years of age. Conclusion Children of parents with RA had consistent excess morbidity. If the associations reflect biological mechanisms, genetic factors seem to play an important role. These findings call for attention given to children of parents with RA.
Source: Annals of the Rheumatic Diseases - Category: Rheumatology Authors: Tags: Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Epidemiology Clinical and epidemiological research Source Type: research
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