Epigenetic Signaling in Glia Controls Presynaptic Homeostatic Plasticity

We present evidence that the SAGA complex is necessary for homeostatic plasticity, demonstrating involvement of four new genes in homeostatic plasticity. This is also evidence that glia participate in presynaptic homeostatic plasticity, invoking previously unexplored intercellular, homeostatic signaling at a tripartite synapse. We show, mechanistically, SAGA signaling regulates the composition of and signaling from the extracellular matrix during homeostatic plasticity.
Source: Neuron - Category: Neuroscience Source Type: research

Related Links:

ConclusionThis is an exemplary case of anFMR1 premutation carrier with significant psychiatric and cognitive issues that demonstrates Fragile X ‐associated Neuropsychiatric Disorders (FXAND) as separate from the other well‐known premutation disorders.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: CLINICAL REPORT Source Type: research
We report on the most advanced techniques for manipulating cerebellar circuits in humans and animal models and define key hurdles and questions for moving forward. PMID: 31165428 [PubMed - as supplied by publisher]
Source: Cerebellum - Category: Neuroscience Authors: Tags: Cerebellum Source Type: research
We report on the most advanced techniques for manipulating cerebellar circuits in humans and animal models and define key hurdles and questions for moving forward.
Source: The Cerebellum - Category: Neurology Source Type: research
Albert Sanfeliu1, Karsten Hokamp2, Michael Gill1 and Daniela Tropea1,3*1Neuropsychiatric Genetics, Department of Psychiatry, School of Medicine, Trinity Translational Medicine Institute, St James Hospital, Dublin, Ireland2Department of Genetics, School of Genetics and Microbiology, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland3Department of Psychiatry, School of Medicine, Trinity College Institute for Neuroscience, Trinity College Dublin, Dublin, IrelandRett syndrome is a rare neuropsychiatric disorder with a wide symptomatology including impaired communication and movement, cardio-respiratory abno...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
We report on a 38-year-old patient with adult-onset psychotic symptoms on a background of infantile-onset seizures, autistic features and episodic ataxia. Whole-exome sequencing revealed a de-novo novel SCN2A mutation (c.4966T > C, p.Ser1656Pro). This and other SCN2A mutations associated with the schizophrenia phenotype overlap those seen in neurodevelopmental disorders, suggesting a common underlying mechanism. This is the first report of a patient with the entire known SCN2A phenotypic spectrum. We highlight the importance of recognizing the psychiatric phenotypes associated with SCN2A mutations and that...
Source: Psychiatric Genetics - Category: Genetics & Stem Cells Tags: Brief Reports Source Type: research
AbstractWith continuing cooperation from 18 domestic and international brain banks over the last 36  years, we have analyzed the aluminum content of the temporal lobe neocortex of 511 high-quality human female brain samples from 16 diverse neurological and neurodegenerative disorders, including 2 groups of age-matched controls. Temporal lobes (Brodmann areas A20–A22) were selected for analysis because of their availability and their central role in massive information-processing operations including efferent-signal integration, cognition, and memory formation. We used the analytical technique of (i) Zeeman-type ...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
You know that raisin bagel or bowl of bran cereal you have every morning, or the plate of pasta or spaghetti you have for dinner? Each and every serving erodes the health of your brain. Some of the effects are reversible, while others are cumulative and irreversible. But understand the concepts behind living the Wheat Belly wheat/grain-free lifestyle and you are enormously empowered in regaining control over health, weight, and youthfulness. Transcript: Hi everybody, Doctor William Davis here. Why do I call this Bagel Brain? Well, a number of reasons — consumption of modern wheat and closely-related grains have a w...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates adhd appetite autism autoimmune cognitive dementia Depression Gliadin gluten-free grain-free grains wheat belly Source Type: blogs
Abstract In the context of neurodegeneration and aging, the cerebellum is an enigma. Genetic markers of cellular aging in cerebellum accumulate more slowly than in the rest of the brain, and it generates unknown factors that may slow or even reverse neurodegenerative pathology in animal models of Alzheimer's Disease (AD). Cerebellum shows increased activity in early AD and Parkinson's disease (PD), suggesting a compensatory function that may mitigate early symptoms of neurodegenerative pathophysiology. Perhaps most notably, different parts of the brain accumulate neuropathological markers of AD in a recognized pro...
Source: Neurobiology of Learning and Memory - Category: Neurology Authors: Tags: Neurobiol Learn Mem Source Type: research
Publication date: Available online 9 August 2018Source: NeuroImageAuthor(s): Aaron Carass, Jennifer L. Cuzzocreo, Shuo Han, Carlos R. Hernandez-Castillo, Paul E. Rasser, Melanie Ganz, Vincent Beliveau, Jose Dolz, Ismail Ben Ayed, Christian Desrosiers, Benjamin Thyreau, José E. Romero, Pierrick Coupé, José V. Manjón, Vladimir S. Fonov, D. Louis Collins, Sarah H. Ying, Chiadi U. Onyike, Deana Crocetti, Bennett A. LandmanAbstractThe human cerebellum plays an essential role in motor control, is involved in cognitive function (i.e., attention, working memory, and language), and helps to regulate emot...
Source: NeuroImage - Category: Neuroscience Source Type: research
Something’s just not right: lately you are forgetful, stressed, and tired all of the time. Symptoms can vary from mood swings, to lack of concentration, to feeling chronically tired, and anxious. To top it off, no matter how healthy you try to eat, you still aren’t losing weight. So let’s add frustrated to the list. And you’re finding that all of this is affecting your performance at work, as a parent, and even as a partner/spouse. It’s not your imagination.  Grains are behind it all… The grains you consume may have numerous damaging effects on your brain and nervous system, not ju...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates adhd anxiety appetite control blood sugar brain brain fog Brain function dementia Dr. Davis grain grains Inflammation learning ability libido mood mood swings psychiatric disorders seizures Source Type: blogs
More News: Ataxia | Autism | Brain | Genetics | Learning | Neurology | Neuroscience | Schizophrenia | Universities & Medical Training