Vitamin D Deficiency Induces Insulin Resistance and Re ‐supplementation Attenuates Hepatic Glucose Output Via the PI3K‐AKT‐FOXO1 Mediated Pathway

ConclusionsOur results demonstrate that vitamin D deficiency induces insulin resistance. Its supplementation has significant beneficial effects on pathophysiological mechanisms in T2D but only in lean and not in the obese phenotype. The increased subacute inflammation and insulin resistance in obesity could not be significantly alleviated by vitamin D supplementation. This needs to be taken consideration in the design of new clinical trials.This article is protected by copyright. All rights reserved

Source: Molecular Nutrition and Food Research - December 3, 2019 Category: Food Science Authors: Shivaprakash Jagalur Mutt, Ghulam Shere Raza, Markus J M äkinen, Sirkka Keinänen‐Kiukaanniemi, Marjo‐Riitta Järvelin, Karl‐Heinz Herzig Tags: Research Article Source Type: research