Development and assesment of nano-technologies for cancer treatment: cytotoxicity and hyperthermia laboratory studies.

Development and assesment of nano-technologies for cancer treatment: cytotoxicity and hyperthermia laboratory studies. Cancer Invest. 2019 Dec 02;:1-38 Authors: Medina-Ramírez IE, Díaz de León Olmos MA, Muñoz Ortega MH, Zapien JA, Betancourt I, Santoyo-Elvira N Abstract Cancer treatment by magnetic hyperthermia offers numerous advantages, but for practical applications many variables still need to be adjusted before developing a controlled and reproducible cancer treatment that is bio-compatible (non-damaging) to healthy cells. In this work, Fe3O4 and CoFe2O4 were synthesized and systematically studied for the development of efficient therapeutic agents for applications in hyperthermia. The biocompatibility of the materials was further evaluated using HepG2 cells as biological model. Colorimetric and microscopic techniques were used to evaluate the interaction of Magnetic Nano-Materials (MNMs) and HepG2 cells. Finally, the behavior of MNMs was evaluated under the influence of an Alternating Magnetic Field (AMF), observing a more efficient temperature increment for CoFe2O4, a desirable behavior for biomedical applications since lower doses and shorter expositions to alternating magnetic field might be required. PMID: 31791151 [PubMed - as supplied by publisher]
Source: Cancer Investigation - Category: Cancer & Oncology Tags: Cancer Invest Source Type: research