Multifunctional hydrogel based on ionic liquid with antibacterial performance

Publication date: Available online 4 December 2019Source: Journal of Molecular LiquidsAuthor(s): Yang Yu, Zeyu Yang, Shujing Ren, Yanan Gao, Liqiang ZhengAbstractBiocompatible antibacterial hydrogels as novel dressing materials have been a widely researched method in modern medical technology. Here, we designed and prepared a new type of multifunctional antibacterial hydrogels that used poly(vinyl alcohol) (PVA)-tetrahydroxyborate anion (B(OH)4−) hydrogel as a vector and pyrrolidinium ionic liquids (ILs) as antibacterial drugs. The formation of borate ester bonds between PVA and B(OH)4− as dynamic network junctions endows hydrogels with multiple functions. Moreover, the as-prepared hydrogel exhibited effective anti-microbial activity against Escherichia coli and Staphylococcus aureus. Our results indicated that the hydrogels containing ILs with longer alkyl chain exhibited more pronounced antibacterial properties. The moisture retention, self-healing, syringeability and multiresponse behavior together with the antibacterial properties of the hydrogels make them ideal candidates as multifunctional dressing materials for joint skin wound healing.
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research

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Publication date: 2020Source: Toxicology Reports, Volume 7Author(s): Afaf M. Weli, Hanady S. Al-Saadi, Rouqaya S. Al-Fudhaili, Amzad Hossain, Zabida Binti Putit, Mahmood K. JasimAbstractMedicinal plant as herbal medicine is widely used to cure infectious diseases. Rubus fruticosus L (R. fruticosus) has been studied for its antimicrobial and cytotoxic activities. Different polarity leave extracts were prepared by using hexane, chloroform, ethyl acetate and hydro alcoholic solvents. Agar diffusion method has been used to assess the antibacterial activity against two gram-positive Enterococcus faecalis and Staphylococcus aure...
Source: Toxicology Reports - Category: Toxicology Source Type: research
Publication date: Available online 18 January 2020Source: Toxicology ReportsAuthor(s): Afaf M. Weli, Hanady S. Al-Saadi, Rouqaya S. Al-Fudhaili, Amzad Hossain, Zabida Binti Putit, Mahmood K. JasimAbstractMedicinal plant as herbal medicine is widely used to cure infectious diseases. Rubus fruticosus L (R. fruticosus) has been studied for its antimicrobial and cytotoxic activities. Different polarity leave extracts were prepared by using hexane, chloroform, ethyl acetate and hydro alcoholic solvents. Agar diffusion method has been used to assess the antibacterial activity against two gram-positive Enterococcus faecalis and S...
Source: Toxicology Reports - Category: Toxicology Source Type: research
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract Skin and soft tissue infections are major concerns with respect to wound repair. Recently, anti-bacterial wound dressings have been emerging as promising candidates to reduce infection, thus accelerating the wound healing process. This paper presents our work to develop and characterize poly(vinyl alcohol) (PVA)/chitosan (CS)/silk sericin (SS)/tetracycline (TCN) porous nanofibers, with diameters varying from 305 to 425 nm, both in vitro and in vivo for potential applications as wound dressings. The fabricated nanofibers possess a considerable capacity to take up water through swelling (~325-650%). Seric...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
Publication date: April 2020Source: Materials Science and Engineering: C, Volume 109Author(s): Simona Morariu, Maria Bercea, Luiza Madalina Gradinaru, Irina Rosca, Mihaela AvadaneiAbstractPhysical poly(vinyl alcohol) (PVA) hydrogels containing up to 3% Laponite RD (LRD) were obtained by freezing/thawing method. The structure and the morphology of PVA/LRD hydrogels were evaluated by ATR-FTIR and SEM measurements, respectively. The morphological analysis of the hydrogels revealed the formation of clay agglomerates and large size aggregates at LRD concentrations above 2.5%. The rheological and mechanical properties of the PVA...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 28 December 2019Source: Carbohydrate PolymersAuthor(s): Pengfei Zou, Wen-Hui Lee, Zhiqin Gao, Di Qin, Yuxia Wang, Jiao Liu, Tongyi Sun, Yuanyuan GaoAbstractNovel nanomaterials have been developed for antimicrobial and wound healing applications. Here, we report the preparation of a polyvinyl alcohol/chitosan (PVA/CS) nanofiber with carboxymethyl chitosan nanoparticles (CMCS-OH30 NPs) encapsulating the antibacterial peptide OH-CATH30 (OH-30). The PVA/CS nanofibers containing OH-30 NPs (NP-30-NFs) obtained via electrospinning could achieve a secondary embedded OH-30. The effect of NP-30-NFs...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 28 December 2019Source: Materials LettersAuthor(s): Sapna Thakur, Manpreet Kaur, Way Foong Lim, Madan LalAbstractAntimicrobial activity of ZnO nanomaterials has received global interest due to high surface to volume ratio. In the present study, ultra‐thin ZnO nanofibers in poly vinyl alcohol (PVA) has been electrospun. Calcination of mentioned precursor fibers was done at 400 and 500°C for 3hrs, respectively. Rietveld refinement of XRD pattern confirms the hexagonal wurtzite structure (with space group = P63mc) of ZnO nanofibers. SEM images reveal that the ZnO nanofibers have an ave...
Source: Materials Letters - Category: Materials Science Source Type: research
ConclusionsThe SE damaged the cell membrane, with the cytoplasm flowing out, disturbed the synthesis of total protein and phosphorus metabolism, and ultimately killed the bacteria.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: March 2020Source: Materials Science and Engineering: C, Volume 108Author(s): Agni Kumar Biswal, Hariprasad P., Sampa SahaAbstractSimple addition of a minute quantity of non-toxic mustard oil in water/oil/water (W/O/W) double emulsion led to a porous morphology at the surface as well as in the interior of the biodegradable PLGA (Poly(l-lactide-co-glycolide)) microparticles. An attempt was made to understand the mechanism of pore formation by analyzing optical micrographs and SEM images in addition to solution viscosity of organic phase and interfacial tension values between organic and aqueous phases. The ...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 16 November 2019Source: Carbohydrate PolymersAuthor(s): Hossein Rahmani, Seyed Heydar Mahmoudi Najafi, Alireza Ashori, Marzieh Arab Fashapoyeh, Farzaneh Aziz Mohseni, Sara TorkamanAbstractIn this research, biocomposite films containing chitosan (CS), polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP), with different ratios, have been provided. The effects of adding hexamethylene 1, 6-di(aminocarboxysulfonate) (HMDACS) as cross linker and the formation of urea linkage on mechanical properties such as tensile strength and elongation and dynamic-mechanical properties such as storage mod...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
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