Elastase Fibrinolysis as a Marker of Presence, Size and Mechanical Stress of Abdominal Aortic Aneurysms and its Intraluminal Thrombi

Introduction - Most clinically relevant abdominal aortic aneurysms (AAA) contain an intraluminal thrombus (ILT) 1. The ILT entraps neutrophils, which secrete elastase with fibrinolytic activity, the process of which yields specific ‘neutrophil elastase-derived cross-linked fibrin degradation products’ (E-XDP) 2. Our hypothesis was that circulating E-XDP could reveal the presence, size and mechanical stress of AAAs and its ILTs.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research