Discovering New Mechanisms of Action for Metformin

Metformin is a terrible approach to slowing aging in comparison to, say, mTOR inhibition. Slowing aging in this way, by manipulating the operation of an aged cellular metabolism without repairing the underlying damage that causes aging, is in turn a terrible approach to the treatment of aging. Yet metformin attracts a great deal of interest. I believe that most people simply don't care about effect size and reliability. Most popular science materials don't discuss these points, thus putting every intervention on the same footing in the minds of much of the public. Yet effect size and reliability are the very heart of the matter. The animal data on metformin shows it to be unreliable when it comes to effects on life span; results from different studies and different groups are quite varied. The one large human study to examine mortality and life span looked at people with type 2 diabetes, not healthy individuals. It is known that metformin disrupts the operation of mechanisms needed for benefits to health to arise from regular exercise - a significant issue. Lastly, even if taking the human data at face value, the effect size is really just not large enough to care about. Nothing in the research noted here changes any of this. Previously, the only biochemical pathway that was known to be activated by metformin was the AMPK pathway, which researchers discovered stalls cell growth and changes metabolism when nutrients are scarce, as can occur in cancer. But the s...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs

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We describe evidence for substance use as a risk factor for new-onset diabetes, prevalence of use in people with diabetes, evidence linking substance use with diabetes-related health outcomes, and evidence on the management of these co-occurring conditions.
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
ConclusionsAvailable data do not support the hypothesis of an association of DPP4i treatment with malignancies, with a possible beneficial effect for colon-rectal cancer.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
(Natural News) Living with diabetes means lots of health-related worries, and if you’re taking one very popular diabetes drug, you can add cancer to your list of concerns. Metformin, which is given to many people with type 2 diabetes to control high blood sugar, has been found to contain carcinogens in other countries, prompting official...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
Analysis of participants in the Nurses'Health Study (1980-2014; n=73 196) and the Health Professionals Follow-Up Study (1986-2014; n=38 366) found a healthier lifestyle linked to an increased total life expectancy and life expectancy free of cancer, CVD, and type 2 diabetes.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Contributors : Daan R van der Veen ; Emma E Laing ; Sung-Eun Bae ; Jonathan D Johnston ; Derk-Jan Dijk ; Simon N ArcherSeries Type : Expression profiling by arrayOrganism : Mus musculusPolymorphisms in human circadian clock gene PERIOD3 (PER3) are associated with a wide variety of phenotypes such as diurnal preference, delayed sleep phase disorder, sleep homeostasis, cognitive performance, bipolar disorder, type 2 diabetes, cardiac regulation, cancer, light sensitivity, hormone and cytokine secretion, and addiction. However, the molecular mechanisms underlying these phenotypic associations remain unknown.Per3 knockout mice...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
This article is protected by copyright. All rights reserved. PMID: 31944292 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - Category: Physiology Authors: Tags: J Physiol Source Type: research
y Grochowski Metformin (MET), 1,1-dimethylbiguanide hydrochloride, is a biguanide drug used as the first-line medication in the treatment of type 2 diabetes. The recent years have brought many observations showing metformin in its new role. The drug, commonly used in the therapy of diabetes, may also find application in the therapy of a vast variety of tumors. Its effectiveness has been demonstrated in colon, breast, prostate, pancreatic cancer, leukemia, melanoma, lung and endometrial carcinoma, as well as in gliomas. This is especially important in light of the poor options offered to patients in the case of high-gra...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
(CBS Local) — Healthy habits such as exercising for at least 30 minutes a day or drinking in moderation can help you stave off diseases for an extra decade, according to new research. The study, published last week in the British Medical Journal, found that those who led a healthy lifestyle are more likely to be free of illnesses such as cardiovascular disease, cancer and type 2 diabetes. A healthy lifestyle was defined by those with at least four of the following five factors: Never smoking Healthy body mass index (BMI) of 18 to 25 Moderate alcohol intake (no more than a small glass of wine a day for women and a pi...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Offbeat Harvard Local TV talkers Source Type: news
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