MIT Researchers Develop Treatment That Could Make Passing Kidney Stones Less Painful
CAMBRIDGE (CBS) – A new treatment could help ease the passage of kidney stones, according to researchers at MIT and Massachusetts General Hospital. Scientists said this week that muscle relaxants can reduce the contractions that cause pain when passing the stones. About 1 in 10 people will have the painful experience of kidney stones. They cause more than 500,000 emergency room visits in the United States every year. But local researchers think they’ve made a discovery that can help. They say delivering a combination of two muscle relaxants directly to the ureter, the tube that connects the kidneys and bladder, can make passage faster and less painful. MIT engineers used human ureteral smooth muscle cells grown in a lab dish to identify drugs that would help to relax the muscle cells. (Image credit: Christopher Lee and Michael Cima) “We think this could significantly impact kidney stone disease, which affects millions of people,” MIT professor Michael Cima said in a statement. Currently, patients are usually told to wait for the stones to pass and given painkillers as well as an oral medication that is supposed to help relax the ureter, but it’s unclear if that treatment is effective. “If you look at how kidney stones are treated today, it hasn’t really changed since about 1980, and there’s a pretty substantial amount of evidence that the drugs given don’t work very well,” lead study author Christopher Lee said. &ldq...
Publication date: Available online 23 September 2020Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): Vincent Laudenbach, Aude Charollais, Sophie Radi, Marie-Hélène Stumpf, Anne Vincent, Ingrid Kaltwasser, Tiphaine Tomczyk, Jacques Benichou, Philippe Leroux, Stéphane Marret
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Conclusion: IL-23 inhibitors are safe and efficacious therapeutic options for patients with psoriasis and should be considered as a potential first-line therapy alone or in combination with topical medications, phototherapy, and other systemic non-biologic agents. Consideration should be given to the evidence-based guidelines of global dermatologic organizations to help guide therapeutic decisions. PMID: 32962478 [PubMed - as supplied by publisher]
This FOA seeks to encourage research addressing major gaps identified in the United States Preventive Services Task Force (USPSTF) recommendation statement concerning interventions to prevent perinatal depression.
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CONCLUSION: SO remains a threatening clinical diagnosis that poses diagnostic and therapeutic challenges. It can be triggered post-traumatic, but also any intraocular surgery. This should be taken into account when assessing the indication for intraocular eye surgery, especially in eyes with reduced visual outcome. PMID: 32967030 [PubMed - as supplied by publisher]
Abstract The case involved a man in his forties. While working at the restaurant that the patient runs, the patient experienced a stab-like pain on the left shoulder and developed systemic pruritic eruptions. He was diagnosed with anaphylaxis upon visiting our emergency department. Conjunctival hyperemia, lip swelling, cold sweats, and nausea presented later. A cap fluorescence enzyme immunoassay using the serum of the patient showed specific immunoglobulin E (IgE) positivity for wasps; therefore, we hypothesized that he had anaphylaxis caused by the insect's sting. Insects of the same species as that by which the...
After significant APA advocacy, the House Veterans ’ Affairs Committee removed a proposal to implement a pilot program allowing clinical psychologists to prescribe and manage medications for veterans who seek care in the Veterans Health Administration.After learning about the proposal, APA issued an advocacy alert that resulted in over 1,000 members sending more than 3,000 letters to their elected officials on Capitol Hill, opposing the proposal and urging lawmakers to ensure veterans receive the highest quality mental health care possible. Similarly, APA leadership, as well as government relations and policy staff m...
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