Doctors 'reanimate' heart for first-of-its-kind transplant in US

Doctors at Duke University Medical Center performed the first donation after circulatory death heart transplant on an adult in the United States on December 1.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news

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Publication date: January 2020Source: The Annals of Thoracic Surgery, Volume 109, Issue 1Author(s): Muhammad Aftab, T. Brett Reece, Lars G. Svensson
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
This study examined whether LVAD exchanges affect posttransplantation outcomes.MethodsThis study focused on adult patients in the Organ Procurement and Transplantation Network database who were bridged to transplant with a LVAD implanted between 2007 and 2017. Patients who underwent LVAD exchange were compared with those supported with a single device. The primary end point was all-cause mortality at 1, 2, and 5 years after transplantation. The impact of device exchange on risk-adjusted outcomes was examined using Cox proportional hazards models.ResultsAmong 8239 patients who met the inclusion criteria, there were 611 pump...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Purpose Left ventricular assist devices (LVAD) are associated with an increased aerobic capacity in patients with chronic heart failure (CHF). However, studies evaluating the impact of LVAD implantation on physical activity (PA) are lacking. The aim of this study was to compare daily PA levels in participants with LVAD with well-matched CHF participants. Methods Sixteen participants with an LVAD (age, 59.1 ± 10.8 yr) were case-matched to 16 participants with advanced CHF (age, 58.3 ± 8.7 yr), who were listed or being considered for cardiac transplantation. Participants underwent a cardiopulmonary exercis...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research
By ANISH KOKA, MD Bobby It took some doing, but I had finally made it to Bobby’s home. It was a rowhome tucked into one of those little side streets in the city that non-city folks wouldn’t dream of driving down. As I step in, I’m met by the usual set up – wooden steps that hug the right side of the wall leading up to the second floor.  Bobby certainly hasn’t made it up to the second floor in some time. At the moment she is sitting in her hospital bed in the living room. The bed is the focal point to a room stuffed to the gills with all manners of stuff. At least three quarters o...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Medical Practice Patients Physicians Anish Koka social injustice Source Type: blogs
Contributors : Kenneth B Margulies ; Thomas P CappolaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe Myocardial Applied Genomics Network (MAGNet; www.med.upenn.edu/magnet), collects and banks human cardiac tissue for genomic research. All subjects or next of kin provided written informed consent for tissue donation and analyses and all study protocols were approved by relevant institutional review boards. Left ventricular free-wall tissue was harvested at the time of cardiac surgery from subjects with heart failure undergoing transplantation and from unused donor hearts with appar...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
CONCLUSIONS Pre-reperfusion caval venting in liver transplantation (in addition to a portal vent and a chilled LR/albumin portal flush solution) appears to have favorable hemodynamic effects. The literature on this technique is sparse and larger studies are needed. PMID: 31831725 [PubMed - in process]
Source: Annals of Transplantation - Category: Transplant Surgery Authors: Tags: Ann Transplant Source Type: research
A new technology that allows the heart to be taken from donors after circulatory death may increase the heart donor pool by as much as 30%.Medscape Medical News
Source: Medscape Transplantation Headlines - Category: Transplant Surgery Tags: Cardiology News Source Type: news
New data suggest a relationship between air pollution and all-cause mortality among heart transplant patients living in ZIP code areas where levels exceed US National Ambient Air Quality Standards limits.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology News Source Type: news
Publication date: Available online 11 December 2019Source: JACC: Heart FailureAuthor(s): Jonathan N. Menachem, Kelly H. Schlendorf, Jeremy A. Mazurek, David P. Bichell, D. Marshall Brinkley, Benjamin P. Frischhertz, Bret A. Mettler, Ashish S. Shah, Sandip Zalawadiya, Wendy Book, JoAnn LindenfeldAbstractAs a result of improvements in care for patients with congenital heart disease (CHD),>90% of children born with CHD are expected to survive to adulthood. For those adults, heart failure (HF) is the leading cause of death. Advances in recognition of, and treatments for, these patients continue to improve. Specifically, adu...
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
Abstract We noted a recent increase in number of immunocompromised children with CMV viremia at our institution. The purpose of this study was to determine the frequency of CMV viremia in this population and evaluate factors associated with drug-resistant mutations. A retrospective review of immunocompromised hosts, 0-21 years of age, who had CMV viremia during 2007-2017. CMV viremia was detected using PCR assays. Genetic mutation assays were performed using PCR sequencing of the phosophotransferase UL 97 gene and the polymerase UL54 gene of CMV using Quest Diagnostics (San Juan Capistrano, CA, USA) or ARUP...
Source: Ann Oncol - Category: Cancer & Oncology Authors: Tags: Pediatr Hematol Oncol Source Type: research
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