Association of Exposure to Toxoplasma gondii, Epstein-Barr Virus, Herpes Simplex Virus Type 1 and Cytomegalovirus with New-Onset Depressive and Anxiety Disorders: an 11-year follow-up study

ConclusionThe results of this large, nationally representative longitudinal study suggest that common viral infections are not significant risk factors for common mental disorders. The association of CMV with a lower risk of generalized anxiety disorder warrants further investigation.
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research

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Source: Anxiety, Stress and Coping - Category: Psychiatry & Psychology Authors: Source Type: research
Source: BMJ - Category: General Medicine Source Type: research
Say you’ve received a brand-new Fitbit for Christmas to get you started in tracking your exercise routine and reach your fitness goals. Great! However, there might be more going on behind the scenes of you keeping fit with the help of technology than meets the eye… At The Medical Futurist, we’re great fans of wearables (or health trackers) that help you make more informed decisions when it comes to your health. However, we can’t stay indifferent to the potential risks which using these devices entail such as individual tracking, inaccuracies and even supplementing harmful behaviours. Just lik...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Health Sensors & Trackers digital health fitness wearables healthcare design fitness trackers digital health sensors Source Type: blogs
Postoperative pain is not adequately managed in greater than 40% of surgical patients and is a high priority for perioperative research. In this meta-analysis, we examined studies comparing postoperative opioid consumption and pain scores in surgical patients who received methadone by any route vs those who received another opioid by any route. Studies were identified from PubMed, Cochrane, Web of Science, EMBASE, and Scopus from January 1966 to November 2018. Pooled odds ratios were calculated for a primary outcome of postoperative opioid consumption and secondary outcomes of time-to-extubation, time-to-first postoperativ...
Source: Pain - Category: Anesthesiology Tags: Systematic Review and Meta-Analysis Source Type: research
The tendency to select threatening over benign interpretations of ambiguous bodily sensations and cues characterises young people with chronic pain. However, previous studies disagree over whether these biases extend to nonbodily harm situations such as social evaluation. Understanding the content of these biases is crucial to the development of pain management strategies seeking to modify such biases. Two hundred forty-three young people aged 16 to 19 years completed an expanded version of the Adolescent Interpretation of Bodily Threat task. Using a factor-analytic approach, we removed items that did not consistently asso...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
We conducted a multicenter, randomized, patient- and assessor-blinded, sham-controlled trial to investigate the efficacy of repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex (M1) in patients with neuropathic pain (NP). Patients were randomly assigned to receive 5 daily sessions of active or sham rTMS of M1 corresponding to the part of the body experiencing the worst pain (500 pulses per session at 5 Hz). Responders were invited to enroll in an open-label continuous trial involving 4 weekly sessions of active rTMS. The primary outcome was a mean decrease in a visual analogue scale of pain inten...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Our objective was to develop comprehensive national estimates of the total burden of herpes zoster (HZ) among U.S. adults, including direct (ie, medical costs) and indirect (ie, productivity losses) costs, as well as its psychosocial impact (ie, quality of life losses). Using a patient-level microsimulation model, we projected health and economic outcomes among U.S. adults aged 18 years and older using a 10-year time horizon. We conducted a comprehensive systematic literature review to generate parameter values and conducted simulation modeling to generate our outcomes, including numbers of cases of uncomplicated HZ, posth...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Chronic pain and anxiety symptoms are frequently encountered clinically, but the neural circuit mechanisms underlying the comorbid anxiety symptoms in pain (CASP) in context of chronic pain remain unclear. Using viral neuronal tracing in mice, we identified a previously unknown pathway whereby glutamatergic neurons from layer 5 of the hindlimb primary somatosensory cortex (S1) (GluS1), a well-known brain region involved in pain processing, project to GABAergic neurons in the caudal dorsolateral striatum (GABAcDLS). In a persistent inflammatory pain model induced by complete Freund's adjuvant injection, enhanced excitation ...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Despite evidence of broad impact on daily functioning in adolescence, little is known regarding the life course effects of childhood chronic pain. This is the first nationally representative study to characterize the disruptive impact of chronic pain in adolescence on key educational, vocational, and social outcomes in young adulthood (12 years later). Data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) were used, including 3174 youth with chronic pain and 11,610 without chronic pain. Multivariate regression analyses controlling for sociodemographic factors and adolescent depression found t...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Low levels of catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, and stress, which potentiates catecholamine release from sympathetic nerves, are fundamental to chronic functional pain syndromes and comorbid depression, which predominantly affect females. Here, we sought to examine the independent and joint contributions of low COMT and stress to chronic functional pain and depression at the behavioral and molecular level. Male and female C57BL/6 mice received sustained systemic delivery of the COMT inhibitor OR486 over 14 days and underwent a swim stress paradigm on days 8 to 10. Pain and depr...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
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