Risk for Hodgkin Lymphoma Increased With Allergic Disease, Eczema

Associations attenuated but remained significant after adjustment for steroid use
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Dermatology, Family Medicine, Internal Medicine, Allergy, Oncology, Pathology, Journal, Source Type: news

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UCLA researchers are part of an international team that reported the use of a stem cell gene therapy to treat nine people with the rare, inherited blood disease known as X-linked chronic granulomatous disease, or X-CGD. Six of those patients are now in remission and have stopped other treatments. Before now, people with X-CGD – which causes recurrent infections, prolonged hospitalizations for treatment, and a shortened lifespan – had to rely on bone marrow donations for a chance at remission.“With this gene therapy, you can use a patient’s own stem cells instead of donor cells for a transplant,&rdqu...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Date: Monday, 02 03, 2020; Speaker: Philip D Hodgkin, Professor, Walter and Eliza Hall Institute; Building: Building 10 (Clinical Center); Lipsett Auditorium
Source: NIH Calendar of Events - Category: American Health Source Type: events
Conditions:   Immunisation;   Shigella Infection Interventions:   Other: Placebo;   Biological: Shigella sonnei strain 53G;   Biological: WRSs2 Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Indoor environmental control practices are effective in reducing asthma symptoms among children. How do these practices differ by race/ethnicity in households with children with asthma in the US?Preventing Chronic Disease
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Public Health & Prevention Journal Article Source Type: news
(NIH/National Institute of Allergy and Infectious Diseases) A Phase 1 clinical trial testing the safety and effectiveness of a monoclonal antibody (mAb) against malaria has begun enrolling healthy adult volunteers at the National Institutes of Health Clinical Center in Bethesda, Maryland. The trial, sponsored by NIH's National Institute of Allergy and Infectious Diseases (NIAID), is the first to test mAb CIS43LS in humans. It aims to enroll up to 73 volunteers aged 18 through 50 years old who have never had malaria.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(University of Alberta Faculty of Medicine&Dentistry) A new study shows cancer cells found in the lesions on the skin of cutaneous T-cell lymphoma patients originate from the blood, not the skin as was believed. The protocol to treat the disease was to eliminate the cancer cells from the skin. Based on the findings, researchers believe it would be more effective to treat the malignant clones in the blood rather than waiting until the cells reach the skin and present as lesions.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Contributors : Niraj Shenoy ; Amit Verma ; Kith PradhanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMajor efforts are underway to identify agents that can potentiate effects of immune checkpoint inhibition. Here, we show that ascorbic acid (AA) treatment caused genome wide demethylation and enhanced expression of endogenous retroviral elements in lymphoma cells. AA also increased 5-hydroxymethylcytosine (5hmC) levels of CD8+ T cells and enhanced their cytotoxic activity in a lymphoma co-culture system. High-dose AA treatment synergized with anti-PD1 therapy in a syngeneic lymphoma ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Amit Verma ; Kith Pradhan ; Niraj ShenoySeries Type : OtherOrganism : Homo sapiensMajor efforts are underway to identify agents that can potentiate effects of immune checkpoint inhibition. Here, we show that ascorbic acid (AA) treatment caused genome wide demethylation and enhanced expression of endogenous retroviral elements in lymphoma cells. AA also increased 5-hydroxymethylcytosine (5hmC) levels of CD8+ T cells and enhanced their cytotoxic activity in a lymphoma co-culture system. High-dose AA treatment synergized with anti-PD1 therapy in a syngeneic lymphoma mouse model, resulting in marked inhibition o...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Amber Sheppard relies on a brand of adrenalin pen that has been recalled because of faults.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Our data support that prior allergic disease, especially eczema, and corticosteroid treatment increase the risk of developing incident Hodgkin ’s lymphoma before the age of 50. Immune system malfunction is central to Hodgkin’s lymphoma development.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
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