Effects of ALS-associated TANK binding kinase 1 mutations on protein-protein interactions and kinase activity [Biochemistry]

Exonic DNA sequence variants in the Tbk1 gene associate with both sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we examine functional defects in 25 missense TBK1 mutations, focusing on kinase activity and protein–protein interactions. We identified kinase domain (KD) mutations that abolish kinase activity or display substrate-specific defects in...

Source: Proceedings of the National Academy of Sciences - December 2, 2019 Category: Science Authors: Junqiang Ye, Jonah Cheung, Valeria Gerbino, Goran Ahlsen, Christina Zimanyi, David Hirsh, Tom Maniatis Tags: Biological Sciences Source Type: research