Epidemiological Impact of Targeted Interventions for People with Diabetes Mellitus on Tuberculosis Transmission in India: Modelling Based Predictions

ConclusionGains can be attained by targeting DM individuals with interventions to reduce TB burden. Most strategies were effective with
Source: Epidemics - Category: Epidemiology Source Type: research

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AbstractTwo global epidemics, diabetes mellitus (DM) and tuberculosis (TB), have converged making their control even more challenging. We herein have reviewed metformin ’s (MTF) effect on patients with active and latent TB, as well as discussed its newly discovered biological mechanisms in mycobacteria. Mounting evidence suggests that MTF provides better outcomes in TB patients, especially those with DM. The mechanisms by which MTF produces its benefits are multi ple. Though metformin’s potential has been proven in patients with DM, larger and more thorough clinical trials, in DM and non-DM-TB patients, need to...
Source: Infection - Category: Infectious Diseases Source Type: research
Conclusion: The Mtb infection status had a significant impact on mycobacterial growth inhibition in PBMC from healthy adults in South Korea, a country with an intermediate burden of tuberculosis, with healthy controls showing the greatest mycobacterial growth inhibition. Introduction Pulmonary tuberculosis (TB) is an airborne infectious disease caused by Mycobacterium tuberculosis (Mtb), which is a significant burden for the world, reaching 9.6 million new TB cases and 1.5 million deaths per year (1). Also, just under a quarter of the global population is latently infected with Mtb, and 5–10% of them will dev...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSION: In conclusion, the present study demonstrated that elevated levels of ICAM-1 in patients with type 2 diabetes mellitus are likely associated with the development of tuberculosis. PMID: 30924911 [PubMed - in process]
Source: Puerto Rico Health Sciences Journal - Category: International Medicine & Public Health Tags: P R Health Sci J Source Type: research
Diabetes mellitus increases the risk of tuberculosis (TB) disease and adverse TB outcomes [1]. Emerging evidence suggests diabetes is also associated with latent TB infection (LTBI), and population-based studies reported the prevalence of LTBI among US adults with diabetes to be more than twice that of adults without diabetes (11.6% versus 4.6%) [2, 3]. Given the rapid increase of global diabetes prevalence in regions with high TB burdens, clinical and public health interventions targeting this co-epidemic would avert substantial morbidity and mortality [4].
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research
Many countries are facing overlapping epidemics of tuberculosis (TB) and diabetes mellitus (DM). Diabetes increases the overall risk of developing Tuberculosis (TB) and contributes to adverse treatment outcome...
Source: BMC Health Services Research - Category: General Medicine Authors: Tags: Research article Source Type: research
Diabetes mellitus (DM) is recognized as an important comorbidity for the development of tuberculosis (TB). With the increase of DM burden globally, concerns have been raised about the emerging co-epidemics of ...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
Tuberculosis (TB) has existed for millennia and remains a major global health problem. In 2015, TB led to approximately 1.4 million deaths [1]. China has the world's third largest TB epidemic, with more than 1.3 million new cases of TB every year [2]. As a consequence of its rapid economic development, aging, changed lifestyles and urbanization, China has also witnessed an escalating epidemic of diabetes mellitus (DM) [3]. DM is a well-known risk factors for the development of pulmonary TB (PTB).
Source: Tuberculosis - Category: Respiratory Medicine Authors: Source Type: research
The converging epidemics of tuberculosis and diabetes mellitus worldwide have immense healthcare implications [1]. Diabetes mellitus adversely impacts tuberculosis treatment outcomes, largely as delayed bacteriological conversion and lower cure, as well as higher relapse and mortality. Worsened drug resistance scenarios may also result. In addition, diabetic patients experience a higher risk of toxicities induced by drugs used for treating drug-susceptible tuberculosis and multidrug-resistant tuberculosis (table 1) [1, 2]. Clearly, these adverse reactions merit better management.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Correspondence Source Type: research
Publication date: May 2017 Source:Biomedical and Environmental Sciences, Volume 30, Issue 5 Author(s): Jun CHENG, Hui ZHANG, Yan Lin ZHAO, Li Xia WANG, Ming Ting CHEN China has a double burden of diabetes mellitus and tuberculosis, and many studies have been carried out on the mutual impact of these two diseases. This paper systematically reviewed studies conducted in China covering the mutual impact of epidemics of diabetes and tuberculosis, the impact of diabetes on multi-drug resistant tuberculosis and on the tuberculosis clinical manifestation and treatment outcome, the yields of bi-directional screening, and economic...
Source: Biomedical and Environmental Sciences - Category: Biomedical Science Source Type: research
Diabetes mellitus (DM) increases tuberculosis (TB) risk, and there is increasing concern over the public health implications of the convergence of these two epidemics. Screening for TB among people with DM is ...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
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