3D-printed models and virtual reality as new tools for image-guided robot-assisted nephron-sparing surgery: a systematic review of the newest evidences

Purpose of review Nowadays, kidney cancer surgery has been focusing on a patient-tailored management, expanding the indication to nephron-sparing surgery (NSS). Starting from computer tomography images, 3D models can be created, allowing a never experienced before understanding of surgical anatomy. Once obtained the models can be printed or virtually visualized with the aid to assist the surgeon in preoperative planning and simulation or intraoperative navigation. The aim of this systematic review is to assess the preoperative and intraoperative impact of 3D printed and virtual imaging for robotic NSS. Recent findings Ten articles were found to meet the inclusion criteria and reviewed. An ‘intermediate’ score was assessed to the overall articles’ quality. A moderate/high risk of bias was recorded for all the studies. Summary 3D-printed models were considered to be more useful during both preoperative simulations and patients’ counseling. These models guaranteed a better comprehension of anatomical structures and surgical procedure. Costs and quality of the materials available represent the two main limits of this developing technology. Instead, in a virtual reality setting the preoperative planning was enhanced by using 3D virtual models in a mixed reality environment. Intraoperatively, the possibility to overlap the 3D model to real anatomy allowed augmented reality procedures. This technology is still a ‘newborn’ and is constantl...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: ROBOTIC SURGERY IN UROLOGY: FACTS AND REALITY: Edited by Firas Abdollah and Alexandre Mottrie Source Type: research

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AbstractThe hallmark of Lynch syndrome (LS)-associated neoplasia is DNA mismatch repair protein (MMR) deficiency. Recent studies have demonstrated that histologically normal colonic crypts in patients with LS can exhibit deficient MMR expression. The aim of this study was to determine the feasibility of detecting MMR deficient crypts in random colonoscopic biopsies of normal mucosa in patients with and without LS. Forty-nine patients, including 33 with LS, 12 without LS, and 4 with germline MMR gene variants of uncertain significance (VUS), were prospectively and blindly evaluated by immunohistochemistry for MMR deficient ...
Source: Familial Cancer - Category: Cancer & Oncology Source Type: research
Publication date: Available online 28 January 2020Source: Urology Case ReportsAuthor(s): Shinro Hata, Satoki AbeAbstractIn the Checkmate-025 trial, nivolumab treatment prolonged overall survival among patients with previously treated advanced renal cell carcinoma (RCC) compared with treatment with everolimus. Although effective, nivolumab is associated with immune-related adverse events (irAEs). However, the occurrence of hematological irAEs is rare. Some studies have reported on nivolumab-induced thrombocytopenia. Nivolumab associated thrombocytopenia in almost all patients improved with administration of various drugs. H...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Clear cell renal cell carcinoma (ccRCC) comprises the majority of kidney cancer death worldwide, whose incidence and mortality are not promising. Identifying ideal biomarkers to construct a more accurate progn...
Source: Cancer Cell International - Category: Cancer & Oncology Authors: Tags: Primary research Source Type: research
ConclusionOur study provides new insights into the mechanism of alternative splicing events in tumorigenesis and their clinical potential for pRCC.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
By regulating the nuclear translocation of β‐catenin and β‐catenin‐mediated oncogenic signals, δ‐catenin promoted proliferation and inhibited apoptosis of renal cancer cells. Abstractδ‐Catenin is a unique member of the catenin family and is proved to be overexpressed in diverse human cancer types. However, the clinical significance and underling mechanism of δ‐catenin expression in renal cell carcinoma (RCC) remain elusive. Herein, we detected the protein expression of δ‐ catenin in 28 clinical specimens of paired renal cancer tissues and normal renal tissues by Western blot ...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
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Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research
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Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
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Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
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