Mechanisms for Dyspnea on Exertion in Children With Obesity and Asthma

Conditions:   Asthma in Children;   Dyspnea; Asthmatic;   Obesity, Childhood Interventions:   Drug: Albuterol;   Other: Control Sponsor:   University of Nevada, Las Vegas Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation. Lin28 as a Target for Nerve Regeneration https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/ Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitoch...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract Medication management in children and adolescents with obesity is challenging because both developmental and pathophysiological changes may impact drug disposition and response. Evidence to date indicates an effect of obesity on drug disposition for certain drugs used in this population. This work identified published studies evaluating drug dosing, pharmacokinetics (PK), and effect in pediatric patients with obesity, focusing on 70 common medications used in a pediatric network of 42 US medical centers. A PubMed search revealed 33 studies providing PK and/or effectiveness data for 23% (16 of 70) of medic...
Source: Obesity - Category: Eating Disorders & Weight Management Authors: Tags: Obesity (Silver Spring) Source Type: research
Some pregnant women with COVID-19 do become severely ill, and the risk may be elevated for those who were obese or had conditions like asthma before pregnancy, a new study suggests.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Among the longevity apps, LifeExtend is the clear winner as of May 2020. The app is evidence-based, has great references and it is free:https://lifeapps.io/apps/life-extend/It is backed by thephysician/entrepreneur Don Brown (LifeOmics) and the University of Indiana, so it is not going away next year.The app is packed with features and you can dig deeper in any of the domains/5 pillars when you have time.LifeExtend is based on 5 scientifically proven health pillars, they appear as 5 columns and you collect points in each pillar. It looks like a game but the benefits are very much real.The app tracks the big 5 longevity pra...
Source: Clinical Cases and Images - Blog - Category: Universities & Medical Training Tags: Apps Longevity Source Type: blogs
THURSDAY, May 21, 2020 -- Some pregnant women with COVID-19 do become severely ill, and the risk may be elevated for those who were obese or had conditions like asthma before pregnancy, a new study suggests. As with all things COVID-19, researchers...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
CONCLUSIONS Proportion and total number of adults at risk of severe Covid-19 are high in Brazil, with wide variation across states and adult subgroups. T hese findings should be considered while designing and implementing prevention measures in Brazil. We argue that these results support broad social isolation measures, particularly when testing capacity for SARS-CoV-2 is limited.
Source: Revista de Saude Publica - Category: International Medicine & Public Health Source Type: research
Conclusions Asthma treatment guided by FENO may be more effective in achieving better asthma outcomes for patients who are not treated with LTRA and who are not obese, compared to standard practice.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Asthma and allergy, Paediatric pulmonology Original Articles: Asthma and Paediatrics Source Type: research
Severe asthma is a high-burden disease. Real-world data on mepolizumab in patients with severe eosinophilic asthma is needed to assess whether the data from randomised controlled trials are applicable in a broader population. The Australian Mepolizumab Registry (AMR) was established with an aim to assess the use, effectiveness and safety of mepolizumab for severe eosinophilic asthma in Australia. Patients (n=309) with severe eosinophilic asthma (median age 60 years, 58% female) commenced mepolizumab. They had poor symptom control (median Asthma Control Questionnaire (ACQ)-5 score of 3.4), frequent exacerbations (media...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Asthma and allergy Original Articles: Asthma Source Type: research
CONCLUSION: The current study highlights the role of Hsp72 and HMGB1/RAGE/ERK1/2 signaling cascade in the pathogenesis of bronchial asthma and its link to obesity, which could be reflected on monitoring, severity grading, and management of this disease. PMID: 32424522 [PubMed - as supplied by publisher]
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
We report a series of febrile pediatric patients with acute heart failure potentially associated with SARS-CoV-2 infection and the multisystem inflammatory syndrome in children (MIS-C) as defined by the US Centers for Disease Control. Methods: Over a two-month period contemporary with the SARS-CoV-2 pandemic in France and Switzerland, we retrospectively collected clinical, biological, therapeutic, and early outcomes data in children who were admitted to pediatric intensive care units in 14 centers for cardiogenic shock, left ventricular dysfunction and severe inflammatory state. Results: Thirty-five children were identifie...
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
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