Scientists use ultrasound to open brain barrier to treating Alzheimer's

The blood-brain barrier, a region of dense cells and blood vessels, keeps drugs from reaching deep parts of the brain. West Virginia University scientists temporarily opened it with ultrasound.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Discussion: In vivo observation of cerebral vasculature demonstrated the effectiveness of HFμDI for the preclinical study of AD, and a potential way for human diagnosis was provided.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Most drugs, genetic materials, and other therapeutic agents are very difficult to use inside the brain because of the blood-brain barrier. There have been attempts to use ultrasound and microbubbles to create temporary passages through the barrier, i...
Source: Medgadget - Category: Medical Devices Authors: Tags: Materials Medicine Nanomedicine Neurology Neurosurgery Source Type: blogs
Condition:   Alzheimer Disease Interventions:   Device: Neuronavigation-guided single-element focused ultrasound transducer;   Drug: Definity;   Other: Magnetic Resonance Imaging (MRI) with or without gadolinium contrast agents;   Other: Positron Emission Tomography (PET);   Other: Amyvid Sponsors:   Elisa Konofagou;   National Institute on Aging (NIA) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, our findings link the calcification of the vascular tissue with the expression of FGF23 in the vessels and with the elevation of circulating levels this hormone. Permanently Boosting Levels of Natural Killer Cells in Mice to Increase Cancer Resistance https://www.fightaging.org/archives/2019/09/permanently-boosting-levels-of-natural-killer-cells-in-mice-to-increase-cancer-resistance/ Researchers here demonstrate a very interesting approach to immunotherapy: they introduce engineered stem cells in mice that will give rise to additional natural killer T cells, boosting the capability of the ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Scanning ultrasound in the absence of blood-brain barrier opening is not sufficient to clear β-amyloid plaques in the APP23 mouse model of Alzheimer's disease. Brain Res Bull. 2019 Aug 07;: Authors: Leinenga G, Koh WK, Götz J Abstract A major challenge in treating brain diseases is presented by the blood-brain barrier (BBB) that constitutes an efficient barrier not only for toxins but also a wide range of therapeutic agents. In overcoming this impediment, ultrasound in combination with intravenously injected microbubbles has emerged as a powerful technology that allows for the selective brai...
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research
Authors: Cipollini V, Sette G, Bossù P, Ciaramella A, Salani F, De Carolis A, Troili F, Orzi F, Giubilei F Abstract AIMS: The aims of this study were to assess vascular dysfunction in patients with Alzheimer disease (AD) by investigating cerebral vasomotor reactivity using transcranial Doppler ultrasound (TCD) and to evaluate any correlations between cerebral vasoreactivity and endothelium dysfunction. Moreover, the frequency of circulating progenitor cells (CPCs) and the blood concentration of vascular/inflammatory markers were evaluated. MATERIALS AND METHODS: We recruited 35 AD subjects and 17 age-mat...
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Aims: The aims of this study were to assess vascular dysfunction in patients with Alzheimer disease (AD) by investigating cerebral vasomotor reactivity using transcranial Doppler ultrasound (TCD) and to evaluate any correlations between cerebral vasoreactivity and endothelium dysfunction. Moreover, the frequency of circulating progenitor cells (CPCs) and the blood concentration of vascular/inflammatory markers were evaluated. Materials and Methods: We recruited 35 AD subjects and 17 age-matched, sex-matched, and education-matched healthy control subjects. Cerebral vasomotor reactivity was assessed by means of the TCD-...
Source: Alzheimer Disease and Associated Disorders - Category: Geriatrics Tags: Original Articles Source Type: research
Publication date: Available online 26 June 2019Source: NeuroImageAuthor(s): Ying Meng, Bradley J. MacIntosh, Zahra Shirzadi, Alex Kiss, Allison Bethune, Chris Heyn, Karim Mithani, Clement Hamani, Sandra E. Black, Kullervo Hynynen, Nir LipsmanAbstractMR-guided focused ultrasound (MRgFUS) can temporarily permeabilize the blood-brain barrier (BBB), noninvasively, to allow therapeutics access to the central nervous system. However, its secondary and potential neuromodulation effects are not well understood. We aimed to characterize the functional impact of MRgFUS BBB opening in human subjects, based the phase I trial in patien...
Source: NeuroImage - Category: Neuroscience Source Type: research
While the blood-brain barrier (BBB) protects the brain from infections, it also makes it difficult to get drugs that treat neurological conditions to where they’re needed. Now, researchers at Columbia University have shown that their ultrasound...
Source: Medgadget - Category: Medical Devices Authors: Tags: Materials Neurology Neurosurgery Oncology Radiology Source Type: blogs
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