Autonomic dysregulation in children with epilepsy with postictal generalized EEG suppression following generalized convulsive seizures

ConclusionsIn summary, the preictal HRV in GCS + PGES was significantly higher than in children with GCS − PGES. The higher remaining postictal RMSSD in children with GCS + PGES is a potential indicator of autonomic dysregulation. In certain children with epilepsy, autonomic dysregulation may contribute to poor recovery from a GCS with subsequent PGES, thereby contributing to SUDEP. Heart rate variability and autonomic regulation in children with epilepsy should be further studied prospectively in order to better understand the mechanism by which PGES may lead to SUDEP.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research