Autonomic dysregulation in children with epilepsy with postictal generalized EEG suppression following generalized convulsive seizures

The objective of this study was to analyze the characteristics of HRV associated with generalized convulsive seizures (GCS) ± PGES in children.MethodsNine hundred and seventy-seven consecutive children who underwent prolonged scalp video-EEG (vEEG) and 1-lead electrocardiogram (ECG) monitoring at the Hospital for Sick Children, Toronto, Ontario, Canada were reviewed retrospectively from 2009 to 2011. Thirty-five children had GCS captured during their vEEG with or without PGES and met inclusion criteria. Children were subdivided into three age groups and compared with age-matched controls: 3–6 years; 7–12 years; and 13–18 years. Interictal HRV was measured at 5 min during N2 sleep. Preictal HRV was measured at 1 h prior to GCS onset, and postictal HRV was measured at 3 min post-GCS cessation. Low frequency (LF: ms2, 0.04–0.15 Hz) and high frequency (HF: ms2, 0.15–0.4 Hz) bands of heart rate oscillations were analyzed during the interictal and preictal periods. The root mean square of successive differences (RMSSDs) was analyzed during the following time points: interictal; preictal; and postictal.ResultsThirty-five children had GCS: 18 children with PGES [3–6 years (n = 2); 7–12 years (n = 6); 13–18 years (n = 10)] and 17 children without PGES [3–6 years (n = 6); 7–12 years (n = 5); 13–18 years (n = 6)]. Seventeen additional age-matched controls were...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research

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The objective of this study was to analyze the characteristics of HRV associated with generalized convulsive seizures (GCS) ± PGES in children. METHODS: Nine hundred and seventy-seven consecutive children who underwent prolonged scalp video-EEG (vEEG) and 1-lead electrocardiogram (ECG) monitoring at the Hospital for Sick Children, Toronto, Ontario, Canada were reviewed retrospectively from 2009 to 2011. Thirty-five children had GCS captured during their vEEG with or without PGES and met inclusion criteria. Children were subdivided into three age groups and compared with age-matched controls: 3-6 years; 7-...
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
Conclusion: The present work also demonstrates the usefulness of the framework of HRV-based anomaly detection that was originally proposed for epileptic seizure prediction. Significance: The proposed method can contribute to preventing accidents caused by drowsy driving.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Abstract Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality, but the relative importance of underlying cardiac and respiratory mechanisms remains unclear. To illuminate the interactions between seizures, respiration, cardiac function, and sleep that contribute to SUDEP risk, here we developed a mouse epilepsy monitoring unit (EMU) to simultaneously record video, electroencephalography (EEG), electromyography (EMG), plethysmography, and electrocardiography (ECG) in a commonly used genetic model of SUDEP, the Kcna1 knockout (Kcna1-/-) mouse. During interictal periods, Kcna...
Source: Neurobiology of Disease - Category: Neurology Authors: Tags: Neurobiol Dis Source Type: research
Authors: Gürbüz G, Perk P, Çokyaman T, Gürbüz ÖB Abstract Background/aim: The purpose of this retrospective study was to determine the effectiveness of oral iron therapy in breath-holding spells and evaluation of electrocardiographical changes Materials and methods: Three hundred twelve children aged 1–48 months and diagnosed with breath-holding spells between January 2017 and April 2018 were included. Patients’ laboratory findings were compared with 100 patients who had one simple febrile seizure. Results: Cyanotic breath-holding spells were diagnosed in 85.3% (n...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
ConclusionsThere was no significant relationship between CRD, SDB, and neuroendocrine status, though all PSGs in those with high SUDEP risk or neuroendocrine dysfunction revealed SDB. Larger studies are needed to further elucidate relationships between CRD, SDB, neuroendocrine factors, and SUDEP.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Karthi Balasubramanian, K Harikumar, Nithin Nagaraj, Sandipan PatiAnnals of Indian Academy of Neurology 2017 20(4):403-407 Progressive loss of heart rate variability (HRV) and complexity are associated with increased risk of mortality in patients with cardiovascular disease and are a candidate marker for patients at risk of sudden cardiac death. HRV is influenced by the cardiac autonomic nervous system (ANS), although it is unclear which arm of the ANS (sympathetic or parasympathetic) needs to be perturbed to increase the complexity of HRV. In this case–control study, we have analyzed the relation between modulation...
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
While privacy concerns, accuracy of data collected, and FDA approval are all concerns in wearable technology, interest in clinical use of the devices has already begun. Some devices in use include: Compact electrocardiogram monitor. According to the American Heart Association, cardiovascular disease and stroke are the two cause of death in American adults. Cardiovascular monitoring is vital to diagnosis and treatment of heart disease, and remote patient monitoring assists with this effort. Wristband to monitor epileptic seizures. A device which can detect seizures in patients who have epilepsy can be used to record the tim...
Source: Dragonfly - Category: Databases & Libraries Authors: Tags: Data Technology Source Type: news
Analyzing disease instantly: the medical tricorder has been one of the most exciting futuristic technologies in medicine since Star Trek. But will it ever get to the black bag of General Practitioners? As a movie fan, I love talking about how the science fiction movies of the last 100 years have shaped our ideas about medical technology. When university students doing film studies asked me to give a talk on how sci-fi influenced medical technology, I dedicated a whole section to technology inspired by Star Trek. The long list includes telepresence, the hypospray for painless injections, voice–activated communicators,...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Portable Diagnostics GC1 Source Type: blogs
Conclusion In closing, our patient’s episode of TGA combined with her emotional and perceptual response lends credence to the proposal of a “fear/paranoia” circuit in the genesis of paranoid delusions—a circuit incorporating amygdala, frontal, and parietal cortices. Here, neutral or irrelevant stimuli, thoughts, and percepts come to engender fear and anxiety, while dysfunction in frontoparietal circuitry engenders inappropriate social predictions and maladaptive inferences about the intentions of others.[54] Hippocampus relays information about contextual information based on past experiences and th...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Anxiety Disorders Behavioral and Cognitive Neurology Case Report Cognition Current Issue Dementia Medical Issues Neurologic Systems and Symptoms Psychiatry Schizophrenia delusions hippocampus neurobiology Transient global amnesia Source Type: research
Conclusion Given emerging evidence that mitochondrial dysfunction, particularly in the electron transport chain needed for cellular energy production, is an underlying pathophysiological mechanism for some varieties of ASD, clinicians should have a high index of suspicion for mitochondrial disease, especially when they encounter a patient with unusual neurological or constitutional symptoms. The prevalence of mitochondrial disease in ASD patients may be as high as five percent, which means that it is not the “zebra”[27] diagnosis that it might be in a non-ASD patient, where prevalence is about 0.01 percent.10 R...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Anxiety Disorders Asperger's syndrome Autism Behavioral and Cognitive Neurology Case Report Current Issue Intellectual Disability Neurologic Systems and Symptoms Pervasive Developmental Disorders ASD autism spectrum disorder dysauton Source Type: research
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