Sofosbuvir–Velpatasvir Fixed Drug Combination for the Treatment of Chronic Hepatitis C Infection in Patients With End-Stage Renal Disease and Kidney Transplantation

ConclusionOur study showed excellent efficacy with the safety profile of this drug combination in end-stage renal disease patients. However, larger prospective studies and multicenter randomized controlled trials are needed for further confirmation.
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research

Related Links:

Publication date: Available online 22 September 2020Source: Academic RadiologyAuthor(s): Waqas T. Qureshi, Rohit Malhotra, Eric J. Schmidlin, Mohamed Ahmed, Amartya Kundu, Abdul Moiz Hafiz, Jennifer Walker, Nikolaos Kakouros
Source: Academic Radiology - Category: Radiology Source Type: research
Publication date: Available online 22 September 2020Source: Social Science &MedicineAuthor(s): Elise Trott Jaramillo, Cathleen E. Willging
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
CONCLUSION: Within the limitations of the present study, attachments with PEEK and PEKK inserts combined with titanium patrices are favorable for long-term use, both for orthogonal and tilted implants. All three attachment systems showed a high variability of the retentive forces at baseline and for subsequent cycles. This should be taken into consideration for clinical use. PMID: 32957206 [PubMed - in process]
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
In conclusion, this study explores the physiological in-situ response of knee cartilage and meniscus, based on stress MRI, and as a function of loading intensity, joint alignment, histological tissue status, and biomechanical properties, as another step towards clinical implementation. PMID: 32957197 [PubMed - in process]
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
Abstract Aponeuroses are stiff sheath-like components of the muscle-tendon unit that play a vital role in force transmission and thus locomotion. There is clear importance of the aponeurosis in musculoskeletal function, but there have been relatively few studies of aponeurosis material properties to date. The goals of this work were to: 1) perform tensile stress-relaxation tests, 2) perform planar biaxial tests, 3) employ computational modeling to the data from 1 to 2, and 4) perform scanning electron microscopy to determine collagen fibril organization for aponeurosis tissue. Viscoelastic modeling and statistical...
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
Abstract Three-dimensional (3D) printing is an efficient technique for the fabrication of electronic devices. It also enables the use conductive of biomaterials in various applications, such as implants and flexible devices. Designing a new bioink is extremely challenging. For bioelectronics devices, bioink materials should be printable, flexible, conductive, harmless to cells, and sufficiently strong to maintain their shape when immersed in nutrients or under pressure. Over the past few years, several flexible conductive bioinks have been developed that are based on composite pastes containing a biopolymer and co...
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
The objectives of this in-vitro study were to investigate the influence of Deep Margin Elevation (DME) and the preparation design (cusp coverage) on the fracture strength and repairability of CAD/CAM manufactured lithium disilicate (LS2) restorations on molars. Sound extracted human molars (n = 60) were randomly divided into 4 groups (n = 15) (inlay without DME (InoD); inlay with DME (IWD); onlay without DME (OnoD); onlay with DME (OnWD)). All samples were aged (1.2 × 106 cycles of 50N, 8000 cycles of 5-55 °C) followed by oblique static loading until fracture. Fracture strength ...
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
This study aimed to investigate the effect of different printing directions (0°, 45°, and 90°) of stereolithography (SLA) 3D printed dentures on stress distribution. Artificial mucosa was fabricated to fit a maxillary edentulous model, which was scanned to generate a standard tessellation language (STL) file. Subsequently, the upper denture was designed using computer-aided design (CAD) software, output as an STL file (master data), and set in three different printing directions (0°, 45°, and 90°). It was printed by the SLA 3D printer using photopolymer resin (n=6, in each printing direction). The s...
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
Abstract Baleen is a resilient and keratinised filter-feeding structure attached to the maxilla of mysticete whales. It is strong and tough, yet a pliant and resilient material, that withstands extreme pressures in the oral cavity during feeding. We investigated the structure, water content, wettability and mechanical properties of baleen of the Southern right (SRW) and Pygmy right whales (PRW), to understand the effects of hydration on the physical and mechanical properties of baleen. Sixty 25 × 15mm baleen subsamples were prepared from one individual of SRW and PRW. Half were hydrated in circulat...
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
CONCLUSIONS: Bonding neither influenced ReA values nor the fracture pattern that were similar between NB and B structures from same ceramic system. The greater the distance from structure edge, the lesser the chance of chipping occurred. PMID: 32957223 [PubMed - in process]
Source: Journal of the Mechanical Behavior of Biomedical Materials - Category: Materials Science Authors: Tags: J Mech Behav Biomed Mater Source Type: research
More News: Chronic Kidney Disease | Cirrhosis | Dialysis | Dyspepsia | Endoscopy | Gastroenterology | Hemodialysis | Hepatitis | Hepatitis B | Hepatitis C | India Health | Kidney Transplant | Kidney Transplantation | PET Scan | Study | Transplants | Urology & Nephrology | Virology