Sofosbuvir–Velpatasvir Fixed Drug Combination for the Treatment of Chronic Hepatitis C Infection in Patients With End-Stage Renal Disease and Kidney Transplantation

ConclusionOur study showed excellent efficacy with the safety profile of this drug combination in end-stage renal disease patients. However, larger prospective studies and multicenter randomized controlled trials are needed for further confirmation.
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research

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Publication date: Available online 20 January 2020Source: Materials Science and Engineering: AAuthor(s): K. Korgiopoulos, M. PekguleryuzAbstractIt was observed that low level of yttrium (Y) has a modifying effect on the Mg17Al12 phase in the binary Mg-6wt%Al casting alloy. Scanning/transmission electron microscopy, mechanical testing and thermodynamic calculations were employed to understand the modification mechanism. It is found that Y at trace level refines the β-Mg17Al12 phase leading to increased tensile elongation and compressive strain to fracture. The refinement effect is lost with further increase in the Y le...
Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
This study aimed to characterize LFTs in a large cohort of participants with acute HIV infection initiating immediate antiretroviral therapy (ART) and examine the association between LFTs and biomarkers of HIV infection and inflammation. METHODS: We measured LFTs at the time of HIV diagnosis and at 4, 12, 24 and 48 weeks after ART initiation in 426 Thai individuals with acute HIV infection from 2009 to 2018. A subset of individuals had data available at 96 and 144 weeks. We excluded individuals with concomitant viral hepatitis. Alanine aminotransferase (ALT) was the primary outcome of interest; values greater...
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
Publication date: Available online 20 January 2020Source: Clinica Chimica ActaAuthor(s): Hanna AntushevichAbstractFecal microbiota transplantation (FMT) is the introduction (transplantation) of gut microbiota obtained from the faeces of a healthy donor into the patient’s gastrointestinal tract. Most often, such therapy is used the treatment of gastrointestinal diseases caused by the activity of pathogenic or conditionally pathogenic microorganisms, however, recently an increasing number of studies have reported the use of fecal microbiota transplantation for the treatment of diseases such as metabolic syndrome, diabe...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Publication date: Available online 20 January 2020Source: Food HydrocolloidsAuthor(s): Yuying Wang, Anqi Zhang, Xibo Wang, Ning Xu, Lianzhou JiangAbstractFor the first time, the irradiation technology combined with Maillard reaction were used to improve the freeze - thaw stability of soybean protein emulsion. The freeze-thaw stability of emulsions prepared with soy protein isolate (SPI), soy protein isolate and maltose mixture (SPI+M) or glycosylated soy protein isolate with maltose formed by irradiation of 7.5 kGy and 12.5 kGy (named SPI-M7.5 and SPI-M12.5, respectively) was compared. Fourier transform infrared spectrosco...
Source: Food Hydrocolloids - Category: Food Science Source Type: research
Publication date: Available online 20 January 2020Source: Food HydrocolloidsAuthor(s): Mourad Jridi, Ola Abdelhedi, Ali Salem, Hela Kechaou, Moncef Nasri, Yosra MenchariAbstractThe physicochemical, thermal and mechanical properties of blood orange peel pectin (BOPP) film blended with fish gelatin (F-G), at different ratios, were investigated. BOPP was first, tested for its antioxidant capacity, monitored through the β-carotene bleaching, DPPH radical-scavenging and reducing power activities. BOPP and gelatin blending was found to reduce the wettability of the gelatin film, whereas it slightly reduced its transparency....
Source: Food Hydrocolloids - Category: Food Science Source Type: research
Publication date: Available online 20 January 2020Source: Food BioscienceAuthor(s): Francesca Valerio, Maria Grazia Volpe, Gabriella Santagata, Floriana Boscaino, Costantina Barbarisi, Mariaelena Di Biase, Anna Rita Bavaro, Stella Lisa Lonigro, Paola LavermicoccaAbstractA pectin coated dehydrated apple snack containing ≥9 log colony forming units/20 g portion of the probiotic Lactobacillus paracasei IMPC2.1, was developed. The strain was incorporated into the apple slices using vacuum impregnation (IP1) or soaking/stirring (IP2); apple slices were then coated with citrus pectin and dehydrated at 4 °C for 14 days...
Source: Food Bioscience - Category: Food Science Source Type: research
Publication date: Available online 20 January 2020Source: Molecular and Biochemical ParasitologyAuthor(s): Adebanjo Najeem Adedoja, Timothy McMahan, John Patrick Neal, Siddhartha Hamal Dhakal, Seetharama Jois, Daniel Romo, Ken Hull, Srinivas GarlapatiAbstractTranslation initiation factor eIF4F is essential for cap-dependent translation initiation in eukaryotes. eIF4F is a trimeric complex consisting of a scaffold protein eIF4G, cap-binding protein eIF4E and DEAD-box RNA helicase eIF4A. eIF4F binds to the 5’ cap structure of the mRNA through eIF4E and facilitates the binding of the preinitiation complex (PIC) via prot...
Source: Molecular and Biochemical Parasitology - Category: Parasitology Source Type: research
Authors: Tönshoff B Abstract Introduction: The goal of immunosuppressive therapy post-transplantation in pediatric renal transplant recipients is to prevent acute and chronic rejection while minimizing drug side effects. Most therapies alter immune response mechanisms but are not immunologically specific, and a careful balance is required to find the dose that prevents rejection of the graft, while minimizing the risks of over-immunosuppression leading to infection and cancer.Areas covered: This review article focuses on immunosuppressive therapy in pediatric renal transplant recipients, but many aspects can b...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
Authors: Augstburger E, Héron E, Abanou A, Habas C, Baudouin C, Labbé A Abstract Ischemic optic neuropathies are among the leading causes of severe visual acuity loss in people over 50 years of age. They constitute a set of various entities that are clinically, etiologically and therapeutically different. Anatomically, it is necessary to distinguish anterior and posterior forms. From an etiological point of view, the diagnosis of the arteritic form due to giant cell arteritis requires emergent management to prevent blindness and even death in the absence of prompt corticosteroid treatment. When this d...
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Those who consume up to 20 drinks per week are less likely to develop chronic kidney disease than never drinkers, but authors warn"potential benefits" of alcohol must be weighed against"harms."Medscape Medical News
Source: Medscape Transplantation Headlines - Category: Transplant Surgery Tags: Nephrology News Source Type: news
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