Functional cytochrome P450 1A enzymes are induced in mouse and human islets following pollutant exposure

Conclusions/interpretationTransient exposure to TCDD results in long-term upregulation of CYP1A1 enzyme activity in islets. This provides evidence for direct exposure of islets to lipophilic pollutants in vivo and may have implications for islet physiology.
Source: Diabetologia - Category: Endocrinology Source Type: research