Rationale and Design of the British Heart Foundation (BHF) coronary microvascular function and CT coronary angiogram (CorCTCA) study

Publication date: Available online 2 December 2019Source: American Heart JournalAuthor(s): Novalia P Sidik, Margaret McEntegart, Giles Roditi, Thomas J Ford, Michael McDermott, Andrew Morrow, John Byrne, Jacqueline Adams, Allister Hargreaves, Keith G Oldroyd, David Stobo, Olivia Wu, Claudia-Martina Messow, Alex McConnachie, Colin BerryBackgroundMicrovascular and/or vasospastic angina are relevant causes of ischemia and no obstructive coronary artery disease (INOCA) in patients after computed tomography coronary angiography (CTCA).ObjectivesOur research has two objectives. The first is to undertake a diagnostic study and the second is to undertake a nested, clinical trial of stratified medicine.DesignA prospective, multicenter, randomized, blinded, sham-controlled trial of stratified medicine (NCT03477890). All-comers referred for clinically-indicated CTCA for investigation of suspected coronary artery disease (CAD) will be screened in 3 regional centers. Following informed consent, eligible patients with angina symptoms are enrolled before CTCA and remain eligible if CTCA excludes obstructive CAD.Diagnostic study: Invasive coronary angiography involving an interventional diagnostic procedure (IDP) to assess for disease endotypes: 1. Angina due to obstructive CAD (fractional flow reserve (FFR) ≤0.80); 2. Microvascular angina (coronary flow reserve (CFR) 25); 3. Microvascular angina due to small vessel spasm (acetylcholine); 4. Vasospastic angina due to epicardial coronary s...
Source: American Heart Journal - Category: Cardiology Source Type: research

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ConclusionThis is one of the first studies to examine subcortical morphology of basal ganglia and thalamic regions related to StD in adolescents, and the first study to report mostly positive associations between StD, volume and outward morphology in youths. These findings could reflect intact neurogenesis or resilience to depression, however longitudinal research is needed to further understand the neurobiology of StD in adolescents.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
This week’s Psychology Around the Net explores how anxiety looks in children, how managers can work with employees dealing with depression, why young girls are struggling more with mental health issues than their male counterparts, a new bill that would make mental health a priority for first responders, and more.     Anxiety is Different for Kids: Do you have a child who struggles with anxiety? Would you even recognize it? According to the author, anxiety disorders in children can manifest in a variety of ways, and kids typically don’t display symptoms in the same way that adults do. Michigan-based ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic Children and Teens Depression Disorders General Mental Health and Wellness Psychology Psychology Around the Net Research Students Trauma Childhood Anxiety Childhood Trauma First Responders girls' mental health Source Type: blogs
This study examines temporal relationships between 3 dimensions of social support (social connectedness, dyadic satisfaction, and perceived support), and psychological distress in a sample of NG/R spouses during the first year after a service member returns from deployment. Data from 103 military spouses were drawn from a larger intervention development study. Autoregressive cross-lagged panel analyses examined the stress-buffering and support erosion hypotheses over a 3-month period. DRS were measured by the cumulative number of deployments and duration of most recent deployment. Distress was assessed using latent variabl...
Source: The American Journal of Orthopsychiatry - Category: Psychiatry Tags: Am J Orthopsychiatry Source Type: research
AbstractHidradenitis suppurativa (HS) is a chronic, recurrent skin inflammatory disease associated with a variety of comorbidities, like reduced quality of life, metabolic syndrome, sexual dysfunction, working disability, axial spondyloarthritis, inflammatory bowel disease, depression, and anxiety. Like psoriasis, HS patients have been found to have higher risk of cardiovascular death and suicide risk. Clinicians should be informed about these comorbidities so that appropriate screening is implemented. All this evidence suggests that for such a chronic, multi-comorbid disease, the use of validated outcomes to assess severi...
Source: Dermatology and Therapy - Category: Dermatology Source Type: research
ConclusionsConsidering the high prevalence of in particular cognitive impairment, and the diversity of impairments, the cognitive and behavioral aspects of Japanese ALS patients should be given more attention clinically.
Source: Journal of Neurology - Category: Neurology Source Type: research
AbstractPurpose of ReviewApproximately 25% of employed individuals engage in shift work, which can substantially alter opportunities for restorative sleep. Being tired on the job can lead to safety risks in professions such as healthcare, first responders, manufacturing, and numerous others. In addition to the physical stress and health consequences of shift work, recent evidence links shift work to poor mental health outcomes. The current review examines the literature from 2016 onward, emphasizing the impact of shift work on mental health.Recent FindingsShift work is associated with considerable impacts on sleep, depress...
Source: Current Psychiatry Reports - Category: Psychiatry Source Type: research
From our partner Kaiser Permanente. There is a silent epidemic. Globally, in increasing numbers, young people are facing mental-health issues. Depression is a leading cause of illness among young people. Anxiety is on the rise. Suicide ranks third as a cause of death for 15- to 19-year-olds and is increasingly becoming a health equity issue: African-American girls in grades nine to 12 were 70% more likely to attempt suicide in 2017, as compared with non-Hispanic white girls of the same age. Unless we act, we will face the repercussions of this epidemic for years. Lives will be shortened, and generations will struggle. Our...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Davos 2020 mental health Source Type: news
Publication date: Available online 16 January 2020Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Waqas Ullah Khan, Giorgia Michelini, Marco BattagliaAbstractPain often co-occurs with depression and anxiety, and together cause considerable social and economic burden. Twin studies have investigated the aetiology of these covariations. However, to our knowledge, no systematic review examining the covariation between these conditions has been conducted. We searched the Cochrane Database of Systematic Reviews, EMBASE, MEDLINE, and PsychInfo for twin studies examining the covariation between pain with depression and/o...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Bias against age is prevalent in many societies, embedded into societal institutions and expressed in individual perceptions and behaviors, and studies have shown that ageism can negatively affect older people’s health. As the aging population around the world continues to grow, these biases could add to already skyrocketing health care costs, say experts. To determine how much ageism can influence older people’s health, researchers at Yale University analyzed 422 studies involving ageism in 45 countries from 1970 to 2017. The studies included data from seven million older people and specifically addressed age ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Aging health Source Type: news
CONCLUSIONS: Sleep disturbances are more frequent in shift workers than DW. Depressive mood and anxiety symptoms were frequently reported in 3S, then EOD. Different shift schedules cab be a determinant of depressive mood and anxiety symptom. PMID: 31942766 [PubMed]
Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
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