Obesity Might Weaken Some Drugs' Effectiveness Against AFib

Millions of Americans have the potentially dangerous irregular heartbeat known as atrial fibrillation.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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MONDAY, Dec. 2, 2019 -- Obesity may cause a differential response to antiarrhythmic drugs (AADs) used to suppress atrial fibrillation (AF), according to a study published online Nov. 27 in JAMA Cardiology. Aylin Ornelas-Loredo, from the University...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
WEDNESDAY, Nov. 27, 2019 -- Millions of Americans have the potentially dangerous irregular heartbeat known as atrial fibrillation. Now, research suggests that being obese might undercut the effectiveness of certain drugs meant to treat AFib. The new...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
In conclusion, T2D impairs vascular function by dysregulated autophagy. Therefore, autophagy could be a potential target for overcoming diabetic microvascular complications. To What Degree Does Loss of Skeletal Muscle with Age Contribute to Immunosenescence? https://www.fightaging.org/archives/2019/11/to-what-degree-does-loss-of-skeletal-muscle-with-age-contribute-to-immunosenescence/ Sarcopenia, the progressive loss of muscle mass and strength, is characteristic of aging. A perhaps surprisingly large fraction of the losses can be averted by strength training, but there are nonetheless inexorable process...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract Epicardial adipose tissue (EAT) is a metabolically activated beige adipose tissue, non-homogeneously surrounding the myocardium. Physiologically, EAT regulates toxic fatty acids, protects the coronary arteries against mechanical strain, regulates proinflammatory cytokines, stimulates the production of nitric oxide, reduces oxidative stress, and works as a thermogenic source against hypothermia. Conversely, EAT has pathologic paracrine interactions with the surrounded vessels, and might favour the onset of atrial fibrillation. In addition, initial atherosclerotic lesions can promote inflammation and trigge...
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
In conclusion, recent evidence provides compelling evidence in support of the link between venous and arterial thrombosis. Future studies are needed to clarify the nature of this association, to assess its extent, and to evaluate its implications for clinical practice.
Source: Internal and Emergency Medicine - Category: Emergency Medicine Source Type: research
Publication date: Available online 22 November 2019Source: Annals of Medicine and SurgeryAuthor(s): Manoj Kumar, Vincent Jiu Jong Ngian, Clarence Yeong, Caitlin Keighley, Huong Van Nguyen, Bin Soo OngAbstractAimTo examine differences in risk factors, clinical features and outcomes of cellulitis between those 75+ years and those
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
Introduction: Pulmonary embolism (PE) is described in 25% of Chronic Obstructive Pulmonary Disease (COPD) hospitalized patients and may simulate or worsen an episode of acute exacerbation. It should be taken into account in COPD patients with clinical worsening.Aim: To assess whether COPD may be an independent risk factor for PE.Methods: We investigated 91 patients (M:F=1:2, mean age of 69 years) hospitalized for PE at our department from January 2014 to February 2016 and divided them in two groups according to the presence of COPD defined according to GOLD guideline: Group1, PE with COPD (54 patients); Group2, PE without ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary embolism Source Type: research
Bariatric surgery may help reduce the recurrence of atrial fibrillation after ablation among obese patients, but it is not without risk. Do the benefits outweigh the risks?Europace
Source: Medscape Radiology Headlines - Category: Radiology Tags: Cardiology Journal Article Source Type: news
Abstract Introduction: Metabolic syndrome (MetS) is defined as an association between diabetes, hypertension, obesity and dyslipidemia and an increased risk of cardiovascular disease. Mitral annular calcification (MAC) is associated with several cardiovascular disorders, including coronary artery disease, atrial fibrillation (AF), heart failure, ischemic stroke and increased mortality. The CHA2DS2-VASc score is used to estimate thromboembolic risk in AF. However, the association among MAC, MetS and thromboembolic risk is unknown and was evaluated in the current study. Methods: The study group consisted of 94 patients with ...
Source: Revista Brasileira de Cirurgia Cardiovascular - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 7 November 2019Source: IJC Heart &VasculatureAuthor(s): Ernaldo G. Marcos, Ruben R. De With, Bart A. Mulder, Isabelle C. Van Gelder, Michiel RienstraAbstractBackgroundWomen are underrepresented in major atrial fibrillation (AF) trials. In addition, data regarding clinical profile and outcome in young AF patients is limited. Therefore we aimed to investigate the clinical profile, AF progression rate and cardiovascular outcome between sexes in patients with young-onset AF.MethodsA total of 497 patients with AF-onset
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
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