Mechanism that triggers the inflammatory process by Mayaro virus is discovered

(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) A Brazilian team at FAPESP-supported Center for Research on Inflammatory Diseases identified the strategy used by immune cells to combat the pathogen Mayaro virus, which causes symptoms similar to those of chikungunya fever.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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Conclusions: From all the circulating mediators measured, we detected differences of IL-10, TNF- α, and CCL2/MCP-1 between arbovirus groups. We hypothesize that CXC10/IP-10, CCL2/MCP-1, and MIF in the CHIKV-infected group could regulate the CHIKV viral load, while CXC10/IP-10, CCL2/MCP-1, and TNF-α in DENV/ZIKV, and CHIKV/ZIKV groups, could regulate ZIKV viral load.Intervirology
Source: Intervirology - Category: Virology Source Type: research
Abstract We estimated the weighted mean basic reproduction number (R0) of chikungunya virus based on outbreak size. R0 was 3.4 (95% CI 2.4-4.2) and varied for 2 primary chikungunya mosquito vectors: 4.1 (95% CI 1.5-6.6) for Aedes aegypti and 2.8 (95% CI 1.8-3.8) for Ae. albopictus. PMID: 32946722 [PubMed - in process]
Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Tags: Emerg Infect Dis Source Type: research
Aedes spp. are responsible for the transmission of many arboviruses, which contribute to rising human morbidity and mortality worldwide. The Aedes aegypti mosquito is a main vector for chikungunya, dengue and yel...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
r U Abstract For a long time, most of the infectious diseases seemed to have become under control. In particular, vaccinations have contributed to this development. In recent years newly occurring bacterial infections caused by multidrug-resistant pathogens and viral infections, such as the chikungunya virus, influenza epidemics and currently the COVID-19 pandemic, are endangering the world population. This specifically affects patients with rheumatological diseases, who often require immunosuppressive therapy and are thus at risk for infections. Vaccinations can protect those affected, both individually and ...
Source: Zeitschrift fur Rheumatologie - Category: Rheumatology Authors: Tags: Z Rheumatol Source Type: research
by Tyler M. Sharp, Talia M. Quandelacy, Laura E. Adams, Jomil Torres Aponte, Matthew J. Lozier, Kyle Ryff, Mitchelle Flores, Aidsa Rivera, Gilberto A. Santiago, Jorge L. Mu ñoz-Jordán, Luisa I. Alvarado, Vanessa Rivera-Amill, Myriam Garcia-Negrón, Stephen H. Waterman, Gabriela Paz-Bailey, Michael A. Johansson, Brenda Rivera-Garcia BackgroundAfter Zika virus (ZIKV) emerged in the Americas, laboratory-based surveillance for arboviral diseases in Puerto Rico was adapted to include ZIKV disease. Methods and findingsSuspected cases of arboviral disease reported to Puerto Rico Department of Health were teste...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Abstract Viruses were identified from male anthropophilic mosquitoes from Mato Grosso (MT) State, Midwest Brazil from February 2017 to January 2018. Mosquitoes tested included Aedes (Stegomyia) aegypti (1139 males; 84 pools), Culex quinquefasciatus (9426 males; 179 pools), Culex sp. (3 males; 3 pools) and Psorophora albigenu (1 male; 1 pool) collected from four cities of MT. Pools were subjected to viral RNA extraction followed by RT-PCRs specific for ten flaviviruses, five alphaviruses and Simbu serogroup of orthobunyaviruses. Positive pools were passaged three times in VERO cells (alphavirus and orthobunyavirus)...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Tags: Infect Genet Evol Source Type: research
Background: Chikungunya (CHIKV), dengue and zika share similar symptoms, which makes a clinical diagnosis complex in regions where the three arboviruses co-circulate. We evaluated the accuracy of the World Health Organization's (WHO) CHIKV case definition against the gold standard of laboratory diagnosis, in individuals with suspicion of arboviral illness seeking care in an urban emergency department (ED) in Rio de Janeiro, Brazil, from January –June 2018.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0635 Source Type: research
Background: From 1995 till 2019, around 147,200 cases of dengue infection and more than 800 deaths are reported from Pakistan. Vector of dengue virus is mosquito Aedes which is capable of transmitting other viral infections like Chikungunya, Zika, and Yellow Fever. From 2016 –2018, Chikungunya infection was reported in 776 patients. With exponential increase in population and utilization of resources, it is important to eradicate this mosquito.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0631 Source Type: research
Background: Emerging and re-emerging infections caused by viruses continue to threaten us. Over the past decades, Singapore has faced threats caused by the SARS coronavirus, influenza, dengue, and chikungunya viruses, just to name a few. To understand the viral pathogenicity as well as control and prevention of the infections, a high containment has been applied for the research of high biorisk pathogens. Here, a standard precaution has been established to remove an inactivated virus samples to low biosafety environment as a business continuous strategy.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0612 Source Type: research
Background: Chikungunya virus (CHIKV) is an enveloped positive-sense RNA virus that belongs to the genus Alphavirus (family Togaviridae). CHIKV is a re-emerging mosquito-borne pathogen that causes high fever, skin rashes and musculoskeletal inflammatory disease with severe joint and muscle pain. The global emergence of CHIKV has caused significant socio-economic burden in affected areas, but there is still no licensed vaccines or antiviral therapies available.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0606 Source Type: research
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