Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second-Generation Amyloid-{beta} Mouse Model

Conclusion: Longitudinal PET in AppNL-G-F knock-in mice enables monitoring of amyloidogenesis and neuroinflammation in homozygous mice but is insensitive to minor changes in heterozygous animals. The combination of PET with behavioral tasks in AppNL-G-F treatment trials is poised to provide important insights in preclinical drug development.

Source: Journal of Nuclear Medicine - December 1, 2019 Category: Nuclear Medicine Authors: Sacher, C., Blume, T., Beyer, L., Peters, F., Eckenweber, F., Sgobio, C., Deussing, M., Albert, N. L., Unterrainer, M., Lindner, S., Gildehaus, F.-J., von Ungern-Sternberg, B., Brzak, I., Neumann, U., Saito, T., Saido, T. C., Bartenstein, P., Rominger, A. Tags: Basic Source Type: research