Imaging of Chemotherapy-Induced Acute Cardiotoxicity with 18F-Labeled Lipophilic Cations

Conclusion: 18F-MitoPhos showed pharmacokinetic parameters suitable for cardiac imaging. A significant dose response of cardiac uptake to doxorubicin treatment was observed before detectable biomarker alterations. 18F-MitoPhos is therefore a promising tracer for imaging chemotherapy-induced cardiotoxicity. To our knowledge, this is the first demonstration of radiolabeled lipophilic cations being used for the PET imaging of chemotherapy-induced cardiotoxicity and indicates the potential application of these compounds in this area.

Source: Journal of Nuclear Medicine - December 1, 2019 Category: Nuclear Medicine Authors: McCluskey, S. P., Haslop, A., Coello, C., Gunn, R. N., Tate, E. W., Southworth, R., Plisson, C., Long, N. J., Wells, L. A. Tags: Basic Source Type: research