Simplified Methods for Quantification of 18F-DCFPyL Uptake in Patients with Prostate Cancer

Conclusion: 18F-DCFPyL kinetics in PCa metastases are best described by a reversible 2-tissue-compartment model. Image-based TBRs were validated as a simplified method to quantify 18F-DCFPyL uptake and might be applied to clinical, whole-body PET scans. SUV does not provide reliable quantification of 18F-DCFPyL uptake.

Source: Journal of Nuclear Medicine - December 1, 2019 Category: Nuclear Medicine Authors: Jansen, B. H. E., Yaqub, M., Voortman, J., Cysouw, M. C. F., Windhorst, A. D., Schuit, R. C., Kramer, G. M., van den Eertwegh, A. J. M., Schwarte, L. A., Hendrikse, N. H., Vis, A. N., van Moorselaar, R. J. A., Hoekstra, O. S., Boellaard, R., Oprea-Lager, Tags: Clinical Source Type: research