Diagnosis, Clinical Features and Implications of Agitated Depression

Agitated “unipolar” depression is a clinical entity characterized by excitement together with depressed mood during the same episode. The clinical picture of agitated “unipolar” depression is characterized by a depressed and anxious mood with inner, psychic agitation, whereas motor agitation may or m ay not be present. Some investigators have conceptualized this disorder as a mixed affective state, laying on the bipolar disorder spectrum, but controversies still persist. The diagnosis of agitated “unipolar” depression has important prognostic and therapeutic implications, with many clinician s reporting difficulties to adequately diagnose and treat it.
Source: The Psychiatric Clinics of North America - Category: Psychiatry Authors: Source Type: research

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Condition:   Bipolar Depression Interventions:   Drug: Mydayis Extended-Release Capsule;   Drug: Placebo Sponsors:   Mayo Clinic;   Lindner Center of HOPE Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: This study demonstrates the potential of the Mood Outcomes Program to create a nationwide "learning health system" for mood disorders. This goal will be further realized as the program expands in reach and scope across additional NNDC sites. PMID: 31960777 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
Comorbidity is the presence of one or more additional conditions co-occurring with a primary condition. In this episode, host schizophrenic Rachel Star Withers with her cohost Gabe Howard will be discussing comorbidity with schizophrenia. Comorbidity is associated with worse health outcomes, more complex clinical management and increased health care costs. Occupational therapist and host of the podcast Occupied, Brock Cook, will be joining us to discuss ways that he works with people with schizophrenia to manage multiple health issues.  Highlights from “Comorbidity with Schizophrenia” Episode [01:28] What ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Antipsychotic Inside Schizophrenia Mental Health and Wellness Psychiatry Psychology Psychotherapy Bipolar disorder and schizophrenia comorbid comorbid psychiatric conditions Comorbidities Comorbidity Diagnosis Of Schizophrenia Livi Source Type: blogs
Authors: Ali Z, Tegin C, El-Mallakh RS Abstract Introduction: Lurasidone has been approved in the United States as a monotherapy and adjunct for acute bipolar I depression, as well as an antipsychotic for patients with schizophrenia.Areas covered: Herein, the authors review the pharmacodynamics and pharmacokinetics of lurasidone as well and the major randomized clinical trials. The authors also provide their expert opinion.Expert opinion: Lurasidone has not been studied in patients with mania or bipolar psychosis. It has been studied, both as a monotherapy and adjunctive treatment to lithium or valproate, in acute ...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Family therapy focused on building communication and problem-solving skills may benefit youth at high risk of bipolar disorder, according to areport inJAMA Psychiatry. Specifically, the study found that youth with mood symptoms and a family history of bipolar disorder who participated in a four-month program with their parents (and, when possible, siblings) had longer periods between symptoms of depression, mania, hypomania, or mixed episodes (mood episodes) than those who participated in a program with less intensive family involvement.Previous studies show that youth at highest risk of progressing to bipolar disorder ear...
Source: Psychiatr News - Category: Psychiatry Tags: bipolar disorder communication David J. Miklowitz depression family therapy family-focused therapy JAMA Psychiatry manic episodes mood episodes mood symptoms problem solving youth Source Type: research
PURPOSE OF REVIEW: Bipolar disorder has the highest rate of suicide of all psychiatric conditions and is approximately 20-30 times that of the general population. The purpose of this review is to discuss findings relevant to bipolar disorder and suicide. R...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
This study aimed to investigate the risk of self-harm following diagnosis of different psychiatric disorders in an Asian population, through a review of inpatient records retrieved from the Hong Kong Clinical Data Analysis and Reporting System (CDARS).MethodsFor this nested case-control study, the inpatient data of people admitted for any reason to Hong Kong public hospitals, between Jan 1, 2000, and Dec 31, 2010, were extracted from CDARS. Cases were people aged 10 years or older who had been admitted to inpatient care with a first-listed record of psychiatric disorder during the study period. The seven psychiatric disord...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
CONCLUSIONS: Although prescribed to very few patients, the impact of clozapine was notable, with fewer symptoms in patients who had more severe illnesses at baseline. Clozapine could prove to be as successful an intervention for late-stage bipolar disorder as it has been in schizophrenia. PMID: 31958979 [PubMed - as supplied by publisher]
Source: Canadian Journal of Psychiatry - Category: Psychiatry Authors: Tags: Can J Psychiatry Source Type: research
Authors: Barton BB, Segger F, Fischer K, Obermeier M, Musil R Abstract Introduction: Antipsychotic-induced weight-gain (AIWG) is a very important, yet often neglected side-effect in the treatment with first and second generation antipsychotics. AIWG can increase the risk of developing metabolic syndrome, diabetes and cardiovascular disease. Meta-analyses mostly concentrate on AIWG in schizophrenic and bipolar patients, even though antipsychotics are prescribed off-label across many other diagnostic groups (e.g. anxiety disorders, depression, autistic disorder).Areas covered: Pub Med and Web of Science were systemat...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
  Have you ever been so pissed off, in a state of absolute rage, and said or done something you completely regret later? Many people living with bipolar disorder understand this feeling all too well: At the time, you feel so righteous, so fueled with this powerful Hercules-like energy, so ready to take on your enemy (or the world), only to think later… What in the world was that all about? Yep, in these moments, the angry response tends to far outweigh the initial trigger. In this episode, Gabe and Jackie discuss the blind rage that many people have experienced. They talk about how to deal with it and how it&r...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anger Bipolar Disorders General Not Crazy Podcast Source Type: blogs
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