Potent reduction of plasma lipoprotein (a) with an antisense oligonucleotide in human subjects does not affect ex vivo fibrinolysis [Patient-Oriented and Epidemiological Research]

In conclusion, potent reductions of Lp(a) in patients with highly elevated Lp(a) levels do not affect ex vivo measures of fibrinolysis; the relevance of any putative antifibrinolytic effects of Lp(a) in vivo needs further study.

Source: The Journal of Lipid Research - December 1, 2019 Category: Lipidology Authors: Boffa, M. B., Marar, T. T., Yeang, C., Viney, N. J., Xia, S., Witztum, J. L., Koschinsky, M. L., Tsimikas, S. Tags: Patient-Oriented and Epidemiological Research Source Type: research