Intention-to-Treat Analyses for Randomized Controlled Trials in Hospice/Palliative Care: The Case for Analyses to be of People Exposed to the Intervention

Minimizing bias in randomized controlled trials (RCTs) includes intention-to-treat analyses. Hospice/palliative care RCTs are constrained by high attrition unpredictable when consenting, including withdrawals between randomization and first exposure to the intervention. Such withdrawals may systematically bias findings away from the new intervention being evaluated if they are considered nonresponders.

Source: Journal of Pain and Symptom Management - November 7, 2019 Category: Palliative Care Authors: Slavica Kochovska, Chao Huang, Miriam J. Johnson, Meera R. Agar, Marie T. Fallon, Stein Kaasa, Jamilla A. Hussain, Russell K. Portenoy, Irene J. Higginson, David C. Currow Tags: Original Article Source Type: research