In vitro and In vivo Assessment of Suitable Reference Region and Kinetic Modelling for the mGluR1 Radioligand [ 11 C]ITDM in Mice

ConclusionsNo suitable reference region could be identified for [11C]ITDM as strongly supported byin vivo andin vitro evidence of specific binding in all brain regions. However, by applying appropriate kinetic models, [11C]ITDM PET imaging represents a promising tool to visualize mGluR1 in the mouse brain.

http://link.springer.com/10.1007/s11307-019-01435-1

Source: Molecular Imaging and Biology - December 1, 2019 Category: Molecular Biology Source Type: research