Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice [RESEARCH]

In this study, we describe a novel, unexplored phenomenon of a potential causal contribution of PZMs in autoreactive T cells in T1D pathogenesis. We expect that exploration of point mutations and studies in human T cells will enable the further delineation of driver genes to target for functional studies. Our findings challenge the classical notions of autoimmunity and open conceptual avenues toward individualized prevention and therapeutics.

Source: Genome Research - December 1, 2019 Category: Genetics & Stem Cells Authors: Alriyami, M., Marchand, L., Li, Q., Du, X., Olivier, M., Polychronakos, C. Tags: RESEARCH Source Type: research