Drug Recall in US Causes Hypoparathyroid Patients Extreme Hardship Drug Recall in US Causes Hypoparathyroid Patients Extreme Hardship
The recent FDA recall of Natpara, an injectable parathyroid hormone (PTH) for severe hypoparathyroidism, is having a major impact on the lives of patients who need replacement PTH for symptom control.Medscape Medical News
This study aimed to identify aberrant DMGs and pathways by comprehensive bioinformatics analysis. The gene expression profile of GSE28094 was downloaded from the Gene Expression Omnibus (GEO) database, and the GEO2R online tool was used to find DMGs. Gene Ontology (GO) functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of the DMGs were performed by using the Database for Annotation Visualization and Integrated Discovery. A protein-protein interaction (PPI) network was constructed with Search Tool for the Retrieval of Interacting Genes. Analysis of modules in the PPI networks was per...
This article aims to discuss the consensus of the expert group on the role of AGP in T2DM patients on OADs and also reviews the various aspects of AGP and its interpretation; and the available evidences for disease management including treatment options based on AGP report. PMID: 31793278 [PubMed - in process]
Authors: Gupta P, Khan M Abstract Millions of people across the globe go without essential medicines resulting in many avoidable deaths each year. It's no secret that the cost of prescription drugs, including the life-saving ones has been rising far faster than inflation over the last few years. If we take the example of diabetes and as India has the largest number of patients with the condition in the world; it has been shown that patients belonging to the low income group in urban India were spending. 27% of their annual income and those in rural India 34% of their annual income on diabetes care; most of which wa...
Conclusion: Prevalence of hypertension was found to be higher among the diabetic group compared to the non- diabetic group (44.8% vs 42.6%), though the difference between the two was not very substantial. We therefore conclude that half of the urban poor are hypertensive even if they are not diabetic. PMID: 31793268 [PubMed - in process]
Conclusion: Pregabalin has a better safety profile and tolerability compared to Duloxetine but the latter is more effective in treating Diabetic Peripheral Neuropathic Pain. However, further studies with a larger sample size and longer duration are required to be conducted for finding the effectiveness of these drugs, specifically in the Indian population. PMID: 31793266 [PubMed - in process]
Conclusion: Those criteria help in predicting the culprit artery; but they cannot replace the invasive procedure in confirming culprit vessel. Conclusion: Those criteria help in predicting the culprit artery; but they cannot replace the invasive procedure in confirming culprit vessel. PMID: 31793265 [PubMed - in process]
Conclusion and Significance: Among the anthropometric markers namely BMI and AG, AG is a better predictor of DM risk. Therefore AG should also be considered along with HbA1c for predicting DM risk. PMID: 31793264 [PubMed - in process]
Conclusion: CER evidence appeared to be associated with prescribing trends in GLP-1 agonists market; however, no associations were found in DPP4 inhibitors market. The translation of evidence into practice can be limited by the availability of superiority trials and timing of their availability. PMID: 31789054 [PubMed - as supplied by publisher]
CONCLUSION: Osteoporotic BMD and osteoporotic fracture history were significantly, and independently, associated with an increased occurrence of echogenic plaques. Ultrasonographic screening of the carotid artery may benefit patients with osteoporosis. PMID: 31787146 [PubMed - in process]
Conclusions: Elderly hip fracture has a high risk of mortality (14%-58%). Thus, expeditious surgery within 24 hours of admission has been advocated in the Western literature to minimize mortality. Mortality rate at 1 year after surgery remains at 10% to 24%. In our study, even with aggressive co-management, the average delay to hip fracture fixation was more than 3 days; however, the 1-year mortality was relatively low (7.7%). This indicates the importance of preoperative optimization and postoperative rehabilitation for independent ambulation and mortality reduction in the elderly population. PMID: 31788160 [PubMed - in process]