AI's clinical role in breast screening comes under scrutiny

The fiercely contested race to demonstrate how artificial intelligence (AI)...Read more on AuntMinnie.comRelated Reading: C-MIMI: AI could cut mammography workload in half AI shows promise for reducing mammography workload AI enhances radiologist performance for DBT Deep learning enhances breast cancer risk assessment SBI: AI improves DBT's performance in dense tissueComments: 12/1/2019 2:21:59 PMHospital-Rad If I were a resident I would think twice before choosing breast fellowship. Although a mammographer won't be replaced by AI completely, I predict that the work volume will decrease dramatically. Screenings will be interpreted by AI and the mammographers will do diagnostics, ultrasound and biopsies which decreases the need for breast imagers dramatically.  As a side note, probably it the time to decrease the number of residents in radiology. I personally don't think this AI will replace radiologists completely during our lifetime but it will decrease the demand for radiologists. It is just a matter of time before the software calls all normal scans normal and leaves the abnormal ones (plus the false positive ones) to the radiologists to interpret. In fact, the software doesn't need to have a good specificity. It just needs to have a high sensitivity. It can call "very normal" exams, normal (which are a great percentage of radiology exams) and then leave the rest to the radiologists.      12/1/2019 2:26:46 PMhey Interesti...
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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Authors: Wang X, Wen Y, Xue L, Lu R, Tang H, Gao N, Zhang J, Xue Q PMID: 31961109 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Authors: Wang P, Xue L, Wang L, Tang H, Lv C, Xue Q PMID: 31961108 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
ConclusionsXJR played an important role in anti-BC through multi-component, multi-target and multi-pathway mechanisms, in which quercetin and ursolic acid may be the key active components. The anticancer effect of multi-component application was better than that of a single component. This study not only deepened our understanding of the role of TCM in the prevention and treatment of diseases, but also provided a reference for the in-depth research, development and application of the ancient medicine.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Source: Anti-Cancer Agents in Medicinal Chemistry - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
Source: Anti-Cancer Agents in Medicinal Chemistry - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
Source: Anti-Cancer Agents in Medicinal Chemistry - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
Conclusion: All health belief model constructs identified a critical problem for adaptation of behavior. Therefore, this gives the opportunity to design and develop community-based intervention and explore new intervention mechanism with an accurate method.Keywords: Behavior, breast, perception, qualitative data, Ethiopia.
Source: African Health Sciences - Category: African Health Source Type: research
Source: International Journal of Nanomedicine - Category: Nanotechnology Tags: Journal of Experimental Pharmacology Source Type: research
ConclusionsOlder women undergoing IVF treatment were not significantly associated with an excess risk of cancer at long-term follow up. Further studies, however, are needed to confirm these findings.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Targeted therapy using monoclonal antibodies conjugated to toxins is gaining space in the treatment of cancer. Here, we report the anti-tumor effect of a new antibody drug conjugate (ADC) delivering a HDAC inhibitor to ErbB2+ solid tumors. Trastuzumab was partially reduced with tris [2-carboxyethyl] phosphine (TCEP) and conjugated to ST7464AA1, the active form of the prodrug HDAC inhibitor ST7612AA1, through a maleimide-thiol linker to obtain the Antibody Drug Conjugate (ADC) ST8176AA1. The average drug/antibody ratio (DAR) was 4.5 as measured by hydrophobic interaction chromatography (HIC). Binding of ST8176AA1 to ErbB2 r...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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