New insights in Coxiella burnetii infection: diagnosis and therapeutic update.

New insights in Coxiella burnetii infection: diagnosis and therapeutic update. Expert Rev Anti Infect Ther. 2019 Nov 29;: Authors: Melenotte C, Million M, Raoult D Abstract Introduction: Coxiella burnetii infection is still challenging physicians, mainly because no international coordination has been stated to standardize the therapeutic strategy and improve the clinical outcomes.Areas covered: Based on the recent knowledge on Q fever, we review here the clinical practices from Q fever diagnosis to therapy. We searched Pubmed and Google Scholar to perform the qualitative synthesis.Expert opinion: Four major critical points are highlighted in this review. The first point is that Q fever diagnosis has been reviewed in the light of the new diagnosis tools, including molecular biology, transthoracic echocardiography and 18F-FDG-PET/CT -scan imaging. Q fever diagnosis results from the presence of a microbiological criterion in addition to a lesional criterion. Second, the identification of the anticardiolipin antibodies as a novel biological predictive marker for acute Q fever complications (haemophagocytic syndrome, acute Q fever endocarditis, alithiasic cholecystitis, hepatitis, and meningitis). Third, the observation of a coincidence between Q fever and NHL that has made persistent C. burnetii infection a risk of non-Hodgkin's lymphoma. Finally, we expose here the close follow-up we proposed from the French National Reference Center for patients with Q feve...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research

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ConclusionSubstantial agreement exists among experts regarding many strong recommendations for the improvement of practice concerning the use of muscle relaxants and reversal agents during anaesthesia. In particular, the French Society of Anaesthesia and Intensive Care (SFAR) recommends the use of a device to monitor neuromuscular blockade throughout anaesthesia.
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
Publication date: Available online 16 January 2020Source: Materials Today: ProceedingsAuthor(s): T. Sathish, S. KarthickAbstractThe main aim of manufacturers is to cast the aluminum alloys without any defects. Hence, in this work we present the casting of aluminum alloy LM25 to manufacture intricate automobile components and compared it with AC4B Nano-composite Alloy through the process of Gravity Die Casting. The mechanical properties of these alloys are characterized by implementing tensile test, hardness test and compressive test. The Scanning Electron Microscope is used further to test the microstructure investigations...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: Available online 16 January 2020Source: Materials Today: ProceedingsAuthor(s): Nurbol Tolganbek, Almagul Mentbayeva, Berik Uzakbaiuly, Kiyoshi Kanamura, Zhumabay BakenovAbstractThe research on solid electrolytes in lithium ion batteries has gained a significant attention recently. NASICON structured Li1+xAlxTi2−x(PO4)3 (LATP) material is interesting as a promising solid electrolyte for Li-ion batteries, because this type of electrolyte is more stable in the air than other types of solid electrolytes. The paper demonstrates the findings on synthesis of LATP material with two different sol-gel and a m...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
The objective function (response) was the drug loading efficiency (DL%). A response surface method (RSM) was applied to define the optimum and significant factors that affect the drug loading process.
Source: Materials Today Communications - Category: Materials Science Source Type: research
Publication date: Available online 17 January 2020Source: Materials Science and Engineering: CAuthor(s): Monika Bil, Ewa Kijeńska-Gawrońska, Eliza Głodkowska-Mrówka, Aneta Manda-Handzlik, Piotr MrówkaAbstractIntegration of multiple features including shape memory, biodegradation, and sustained drug delivery in a single material offers the opportunity to significantly improve the abilities of implantable devices for cardiovascular system regeneration. Two types of shape memory polyurethanes (SMPUs): PU-PLGA and PU-PLLA/PEG differing in soft segments composition that comprising blends of various biodegradabl...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 17 January 2020Source: Materials Science and Engineering: CAuthor(s): Marie-Hélène Thibault, Chloé Comeau, Guillaume Vienneau, Jacques Robichaud, Delilah Brown, Ralf Bruening, Luc J. Martin, Yahia DjaouedAbstractComposite materials aimed at bone tissue engineering need to have suitable bioactivity in order to promote cell proliferation and adhesion. In this article, we study the potential of boronic acids to improve the bioactivity of chitosan-based composite materials. Samples were prepared using boronic acid functionalised chitosan and Bioglass 45S5. These composite...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
This study reports the synthesis of the BiVO4/TiO2 nanocomposite in optimized conditions using the hydrothermal route. By varying many experimental parameters such as the temperature, the hydrothermal reaction time, the pH of the solution and the surfactant’s nature, we have successfully obtained BiVO4 (monoclinic)/TiO2 (anatase) nanomaterials with different morphologies. These materials were characterized by X-ray powder Diffraction (XRD), Infrared Spectroscopy (IR) and Scanning Electron Microscopy (SEM). The as-prepared nanocomposites were employed to manufacture hybrid electrode sensors to detect H2O2. The BiVO4/T...
Source: Materials Research Bulletin - Category: Materials Science Source Type: research
Publication date: Available online 17 January 2020Source: Journal of Materials Science &TechnologyAuthor(s): Mariana X. Milagre, Uyime Donatus, Naga V. Mogili, Rejane Maria P. Silva, Bárbara Victória G. de Viveiros, Victor F. Pereira, Renato A. Antunes, Caruline S.C. Machado, João Victor S. Araujo, Isolda CostaAbstractScanning electrochemical microscopy (SECM) and scanning vibrating electrode technique (SVET) were used to investigate the electrochemical behaviour of the top surface of the 2098-T351 alloy welded by friction stir welding (FSW). The SVET technique was efficient in identifying the cath...
Source: Journal of Materials Science and Technology - Category: Materials Science Source Type: research
The objective of the work is an evaluation of the behaviour of the reaction system constituted by MgSO4 and charcoal. The study also contemplates the obtained materials characterization to verify the MgO formation and evaluating how the properties of the material are suitable for its use as a pH regulator. Thus, in addition to the scanning and X-ray diffraction electron microscopy techniques, the quantification of the reactivity of the product in acid solutions is also expected. The analysis performed with the variables of excess reducing agent and temperature showed that temperature is the variable that most influences th...
Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
Publication date: Available online 17 January 2020Source: CarbonAuthor(s): Zhiyu Zou, Virginia Carnevali, Laerte L. Patera, Matteo Jugovac, Cinzia Cepek, Maria Peressi, Giovanni Comelli, Cristina AfrichAbstractAn operando investigation of graphene growth on (100) grains of polycrystalline nickel (Ni) surfaces was performed by means of variable-temperature scanning tunneling microscopy complemented by density functional theory simulations. A clear description of the atomistic mechanisms ruling the graphene expansion process at the stepped regions of the substrate is provided, showing that different routes can be followed, d...
Source: Carbon - Category: Materials Science Source Type: research
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