Chagas Disease in the United States: a Public Health Approach.

Chagas Disease in the United States: a Public Health Approach. Clin Microbiol Rev. 2019 Dec 18;33(1): Authors: Bern C, Messenger LA, Whitman JD, Maguire JH Abstract SUMMARYTrypanosoma cruzi is the etiological agent of Chagas disease, usually transmitted by triatomine vectors. An estimated 20 to 30% of infected individuals develop potentially lethal cardiac or gastrointestinal disease. Sylvatic transmission cycles exist in the southern United States, involving 11 triatomine vector species and infected mammals such as rodents, opossums, and dogs. Nevertheless, imported chronic T. cruzi infections in migrants from Latin America vastly outnumber locally acquired human cases. Benznidazole is now FDA approved, and clinical and public health efforts are under way by researchers and health departments in a number of states. Making progress will require efforts to improve awareness among providers and patients, data on diagnostic test performance and expanded availability of confirmatory testing, and evidence-based strategies to improve access to appropriate management of Chagas disease in the United States. PMID: 31776135 [PubMed - in process]
Source: Clinical Microbiology Reviews - Category: Microbiology Authors: Tags: Clin Microbiol Rev Source Type: research

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Publication date: Available online 20 January 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Oscar Campetella, Carlos A. Buscaglia, Juan Mucci, María Susana LeguizamónAbstractMany important pathogen-host interactions rely on highly specific carbohydrate binding events. In the case of the protozoan Trypanosoma cruzi, the causative agent of Chagas disease, glycointeractions involving sialic acid (SA) residues are pivotal for parasite infectivity, escape from immune surveillance and pathogenesis. Though unable to synthesize SA de novo, T. cruzi displays a unique trans-Sial...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Triatomines are natural vectors of Chagas disease and are mainly prevalent in the Americas. In China, previous data from decades ago showed that there were two species of triatomine bugs, Triatoma rubrofasciata a...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
Authors: Lizardo K, Ayyappan JP, Ganapathi U, Dutra WO, Qiu Y, Weiss LM, Nagajyothi JF Abstract Chagas disease is caused by Trypanosoma cruzi which is endemic in Latin America. T. cruzi infection results in a latent infection with approximately a third of latently infected patients developing chronic Chagas cardiomyopathy (CCM). CCM is a common cause of cardiomyopathy in endemic regions and has a poor prognosis compared to other cardiomyopathies. The factors responsible for the transition from the asymptomatic indeterminate latent stage of infection to CCM are poorly understood. Our previous studies demonstrated th...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
The etiological agent of Chagas disease, Trypanosoma cruzi, is an obligate intracellular parasite that infects an estimated 7 million people in the Americas, with an at-risk population of 70 million. Despite its recognition as the highest impact parasitic infection of the Americas, Chagas disease continues to receive insufficient attention and resources in order to be effectively combatted. Unlike the other parasitic trypanosomatids that infect humans (Trypanosoma brucei and Leishmania spp.), T. cruzi retains an ancestral mode of phagotrophic feeding via an endocytic organelle known as the cytostome-cytopharynx complex (SP...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
os Taylor Chagas disease, also known as American trypanosomiasis, is classified as a neglected disease by the World Health Organization. For clinical treatment, only two drugs have been on the market, Benznidazole and Nifurtimox, both of which are recommended for use in the acute phase but present low cure rates in the chronic phase. Furthermore, strong side effects may result in discontinuation of this treatment. Faced with this situation, we report the synthesis and trypanocidal activity of 3-benzoyl-flavanones. Novel 3-benzoyl-flavanone derivatives were prepared in satisfactory yields in the 3-step synthetic proc...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
in JC Abstract Previous studies showed that circulating autoantibodies against M2 muscarinic receptors (anti-M2R Ab) are associated with decreased cardiac parasympathetic modulation in patients with chronic Chagas disease (CD). Here we investigated whether the exposure of M2R to such antibodies could impair agonist-induced receptor activation, leading to the inhibition of associated signaling pathways. Preincubation of M2R-expressing HEK 293T cells with serum IgG fractions from chagasic patients with cardiovascular dysautonomia, followed by the addition of carbachol, resulted in the attenuation of agonist-induced ...
Source: Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Clin Immunol Source Type: research
Publication date: Available online 14 January 2020Source: Inorganica Chimica ActaAuthor(s): Dieter RehderAbstractLight is thrown on the impact of vanadium compounds in medicinal issues, including simple inorganic vanadates, such as vanadates stabilized (and thus possibly modified) by organic counter-ions. The main fields of potential medications (and limits thereof) based on vanadium so far do not (yet) enjoy official pharmacological application. However, several sectors of the potentially successful treatment of pathological symptoms with vanadium (coordination) compounds have been thoroughly and mostly successfully inves...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Abstract In Argentina, the main vector of Chagas disease is Triatoma infestans (Klug, 1834). In recent years, the presence of T. infestans was reported in human dwelling after spraying with pyrethroids in several locations in Argentina. The presence of these insects can be attributed, among other factors, to colonization by bugs from sylvatic or peridomestic populations or to the evolution of resistance to insecticides. In both cases, the dispersal of insects is a determining factor. The aim was to determinate the interaction of dispersal with feeding, food resource and resistance to insecticides. Three nutritiona...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
This article is protected by copyright. All rights reserved. PMID: 31943572 [PubMed - as supplied by publisher]
Source: Cell Biology International - Category: Cytology Authors: Tags: Cell Biol Int Source Type: research
Authors: Norman FF, Comeche B, Chamorro S, López-Vélez R Abstract Introduction: Recent increases in population movements have created novel health challenges in many areas of the World, and health policies have been adapted accordingly in several countries. However, screening guidelines for infectious diseases are not standardized and generally do not include comprehensive screening for parasitic infections.Areas covered: Malaria, Chagas disease, leishmaniasis, amebiasis, filariases, strongyloidiasis and schistosomiasis are reviewed, focusing on the challenges posed for their diagnosis and management ...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
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