Unveiling the potentials of Bacteriocin (Pediocin L50) from Pediococcus acidilactici with Antagonist Spectrum in a Caenorhabditis elegans model.

Unveiling the potentials of Bacteriocin (Pediocin L50) from Pediococcus acidilactici with Antagonist Spectrum in a Caenorhabditis elegans model. Int J Biol Macromol. 2019 Nov 27;: Authors: Chelliah R, Saravanakumar K, Banan-Mwine Daliri E, Kim JH, Lee JK, Jo HY, Kim SH, Rani Ramakrishnan S, Hasan Madar I, Wei S, Rubab M, Barathikannan K, Kwame Ofosu F, Subin H, Eun-Ji P, Da Yeong J, Elahi F, Wang MH, Hwan Park J, Ahn J, Kim DH, Jin Park S, Oh DH Abstract Human-milk-based probiotics play a major role in the early colonization and protection of infants against gastrointestinal infection. We investigated potential probiotics in human milk. Among 41 Lactic acid bacteria (LAB) strains, four strains showed high antimicrobial activity against Escherichia coli 0157:H7, Listeria monocytogenes ATCC 15313, Bacillus cereus ATCC 14576, Staphylococcus aureus ATCC 19095, and Helicobacter pylori. The selected LAB strains were tested in simulated gastrointestinal conditions for their survival. Four LAB strains showed high resistance to pepsin (82%-99%), bile with pancreatine stability (96%-100%), and low pH (80%-94%). They showed moderate cell surface hydrophobicity (22%-46%), auto-aggregation abilities (12%-34%), and 70%-80% co-aggregation abilities against L. monocytogenes ATCC 15313, S. aureus ATCC 19095, B. cereus ATCC 14576, and E. coli 0157:H7. All four selected isolates were resistant to gentamicin, imipenem, novobiocin, tetracycline, clindamy...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research