Change in Cognitive Function Over 12 Months Among Patients With an Implantable Cardioverter-Defibrillator.
Change in Cognitive Function Over 12 Months Among Patients With an Implantable Cardioverter-Defibrillator. J Cardiovasc Nurs. 2013 Jul 31; Authors: Kim J, Pressler SJ, Groh WJ Abstract BACKGROUND:: Patients with implantable cardioverter-defibrillators (ICDs) have decreased cognitive function associated with arrhythmic and/or cardiac disorders, such as ischemic cardiomyopathy. Little is known about changes in cognitive function over time among ICD patients. AIMS:: The aim of this study was to evaluate baseline-to-12-month changes in cognitive function in memory (total recall and delayed recall), psychomotor speed, and executive function among ICD patients. METHODS:: In this prospective study, 115 (mean [SD] age, 64.83 [9.06] years, 75% mean) and 77 ICD patients completed baseline and 12-month face-to-face interviews, respectively, which included neuropsychological tests to evaluate cognitive function. RESULTS:: Patients who completed baseline and 12-month testing had decreased total and delayed recall memory (all P
ConclusionTaken together, SMI could protect myocardial mitochondria by promoting myocardial mitochondrial autophagy in septic cardiomyopathy via inhibition of cleavage of Beclin-1 by caspase-3. Our study demonstrates that SMI could represent a novel target for treatment of septic cardiomyopathy.
Publication date: Available online 9 November 2019Source: Artificial Intelligence in MedicineAuthor(s): Amir Talaei-Khoei, Madjid Tavana, James M. WilsonAbstractChronic diseases often cause several medical complications. This paper aims to predict multiple complications among patients with a chronic disease. The literature uses single-task learning algorithms to predict complications independently and assumes no correlation among complications of chronic diseases. We propose two methods (independent prediction of complications with single-task learning and concurrent prediction of complications with multi-task learning) an...
Authors: Zhang Z, Wang J, Zhu Y, Zhang H, Wang H Abstract The aim of the present study was to evaluate the protective effect and mechanism of Astragaloside IV (ASIV) on myocardial injury induced by type 2 diabetes, with a focus on energy metabolism. Blood glucose, the hemodynamic index, left ventricular weight/heart weight (LVW/HW), the left ventricular systolic pressure (LVSP), the left ventricular end diastolic pressure (LVEDP) and cell survival rate were measured in streptozotocin‑induced diabetes model rats. Western blot analysis, PCR, hematoxylin‑eosin and TUNEL staining, flow cytometry...
This study compared the myocardial deformation patterns of ICM and NICM using 2-D speckle tracking echocardiography (2-D STE) and sought to find parameters valuable in the diagnosis and management of dilated cardiomyopathy. The study population comprised 84 consecutive patients with LV end-diastolic dimension>55 mm and ejection fraction (EF)
Recent data indicate that optimal cardiovascular (CV) risk management negates most of the increased CV risk associated with diabetes mellitus1. However there was a persistent increased risk of heart failure (HF). Recent studies showing the beneficial effect of SGLT2 inhibitors in reducing incident heart failure highlights the need for new ways of identifying those at highest risk of heart failure and personalizing therapeutic interventions to this group2. As the onset of HF is mediated by the development of a cardiomyopathy, the use of natriuretic peptide (NP) screening might highlight those at higher risk.
AbstractPeripartum cardiomyopathy (PPCM) occurs toward the end of pregnancy or in the months after delivery without previously known structural heart disease. Development of therapy ‐refractory cardiogenic shock is described in the literature with a limited number of overall presented cases in this young patient cohort. To provide differences and key points in the therapy of end‐stage PPCM patients, we present a case series of four young women with PPCM referred to our depa rtment for potential VA ECMO support.
ConclusionsWe conclude that early MT and antioxidant gene response protects from fibrotic changes in long-term IH-exposed mouse lung. Without this response, pulmonary fibrosis may develop with longer IH exposure.
In a small Canadian cohort, LVEF recovery after peripartum cardiomyopathy was similar for black women and white women, whereas in a US cohort, black women fared worse, as has been seen before.Medscape Medical News
Condition: Hypertrophic Cardiomyopathy Intervention: Diagnostic Test: Non-invasive ECG imaging - CardioInsight test Sponsors: Imperial College London; Imperial College Healthcare NHS Trust; Medtronic; Barts & The London NHS Trust; University of Oxford; Daniel Bagshaw Trust Not yet recruiting
Authors: Ashraf S, Ilyas S, Siddiqui F, Ando T, Shokr M, Panaich S, Briasoulis A, Afonso L, Khan M Abstract The introduction of wearable cardioverter defibrillators (WCD) provides a novel means of protection in select patients at high risk for sudden cardiac death. The WCD can safely record and terminate life-threatening arrhythmias. In this review, we explore the data behind indications for WCD use and discuss its limitations. We searched PubMed, Google Scholar and Cochrane Central Register of controlled trials for relevant studies. The VEST trial, the first randomised controlled trial on WCD use, did not show sta...