Risk of delayed diagnosis in young patients with left ventricular non-compaction - a potential benefit of magnetic resonance imaging.

CONCLUSIONS: The high variability of morphological findings and clinical manifestations of LVNC results in frequent overlooking of this disorder. Therefore, it is important to make the specialists more familiar with this condition and its pathology. Magnetic resonance imaging represents a conducive method to make correct diagnosis of LVNC under several specific conditions, particularly in case of non-conclusive echocardiographic finding. PMID: 31785212 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Related Links:

Conclusions: We suggest some distinct molecular mechanisms for production of IL-1β in innate immune cells from patients with different clinical forms of Chagas disease. MMP-2 and MMP-9 gelatinases are associated with distinct disease outcomes and IL-1β production. Introduction Chagas disease, also known as American trypanosomiasis, is a neglected parasitic disease caused by the protozoan Trypanosoma cruzi (1), that affects millions of people in the world (2). During the acute phase, a diffuse and intense inflammation in the cardiomyocytes is observed, which is composed mainly of neutrophils, monocytes, and ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Discussion Barth syndrome is characterized by a dilated cardiomyopathy, proximal skeletal muscle weakness, neutropenia and short stature that usually presents at birth or soon after. It is a rare X-linked recessive disease process caused by mutations in the TAZ gene. The TAZ gene codes for tafazzin which alters cardiolipin in mitochondria. Characteristic facies can be seen especially in infancy including a tall and broad forehead, prominent chin and full cheeks, larger ears, and deep-set eyes. Most patients present at birth or soon afterwards but some may not until later in life. Life expectancy is reduced with many childr...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Abstract Friedreich's ataxia (FRDA), which occurs in 1/50000 live births, is the most prevalent inherited neuromuscular disorder. Nearly all FRDA patients develop cardiomyopathy at some point in their lives. The clinical manifestations of FRDA include ataxia of the limbs and trunk, dysarthria, diabetes mellitus, and cardiac diseases. However, the broad clinical spectrum makes FRDA difficult to identify. The diagnosis of FRDA is based on the presence of suspicious clinical factors, the use of the Harding criteria and, more recently, the use of genetic testing for identifying the expansion of a triplet nucleotide se...
Source: World Journal of Cardiology - Category: Cardiology Authors: Tags: World J Cardiol Source Type: research
Conclusion: The findings of the study showed that NGAL associated with NT-proBNP was a stronger predictor of the primary endpoint than NGAL or NT-proBNP alone. The level of NGAL was rising in hypertension, ischemia, anemia, hypoalbuminemia, diabetes or arrhythmias.Kidney Blood Press Res 2018;43:1865 –1877
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research
ConclusionPatients who are at risk for SCA are patients who have had a cardiac arrest due to ventricular fibrillation (VF) or sustained ventricular tachycardia (SVT), those with familial or inherited condition with sudden cardiac arrest risk, myocardial infarction with an ejection fraction (EF) of less than or equal to 35%, dilated cardiomyopathy (including NICM), with an EF of less than or equal to 35%, ICD explanations, and other conditions with high risk of ventricular tachycardia (VT) or VF are candidates for the WCD.The sample of data was from 186 patients. However, more patients were likely candidates but may not hav...
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
Conclusions: The findings suggest that biologically plausible genetic factors may alter susceptibility to PM10-associated QT prolongation in populations protected by the U.S. Environmental Protection Agency’s National Ambient Air Quality Standards. Independent replication and functional characterization are necessary to validate our findings. https://doi.org/10.1289/EHP347 Received: 11 April 2016 Revised: 07 September 2016 Accepted: 19 September 2016 Published: 08 June 2017 Address correspondence to R. Gondalia, Department of Epidemiology, University of North Carolina, 137 E. Franklin St., Chapel Hill, NC 27514...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Fragmented QRS (fQRS) results from localised disruption of conduction due to myocardial fibrosis and scar and is evident on 12-lead ECG. Inhomogeneous myocardial electrical activation consequently manifests as spikes within the QRS complex. fQRS has been shown to be associated with increased mortality, ventricular arrhythmias and major adverse coronary events across a spectrum of pathologies ranging from coronary artery disease, cardiomyopathies (dilated cardiomyopathy, hypertrophic cardiomyopathy and left ventricular non-compaction) to acute pulmonary embolism.1 fQRS has also been defined as a marker of arrhythmogenic rig...
Source: Heart - Category: Cardiology Authors: Tags: Dilated cardiomyopathy, Hypertrophic cardiomyopathy, Congenital heart disease, Drugs: cardiovascular system, Heart failure, Hypertension, Venous thromboembolism, Epidemiology Editorials Source Type: research
CONCLUSIONS: A non-invasive approach including clinical, laboratory and imaging evaluation is key for early CVD detection in SLE. PMID: 27687024 [PubMed - as supplied by publisher]
Source: Lupus - Category: Rheumatology Authors: Tags: Lupus Source Type: research
Abstract AimsInflammatory heart disease represents an important cause of chronic dilated cardiomyopathy (DCM). Predicting the clinical course of patients with inflammatory cardiomyopathy (iCMP) is difficult, and the prognostic value of current biological markers remains controversial. We tested whether expression of selected microRNAs in endomyocardial biopsies (EMBs) is related to LV functional recovery and clinical events in iCMP patients. Methods and resultsEMBs were obtained from patients with iCMP (n = 76) and non‐inflammatory DCM (n = 22). A set of six microRNAs implicated in inflammation (miR‐155 and miR‐146b)...
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Original Article Source Type: research
Abstract AimsInflammatory heart disease represents an important cause of chronic dilated cardiomyopathy (DCM). Predicting the clinical course of patients with inflammatory cardiomyopathy (iCMP) is difficult, and the prognostic value of current biological markers remains controversial. We tested whether expression of selected microRNAs in endomyocardial biopsies (EMBs) is related to LV functional recovery and clinical events in iCMP patients. Methods and resultsEMBs were obtained from patients with iCMP (n = 76) and non‐inflammatory DCM (n = 22). A set of six microRNAs implicated in inflammation (miR‐155 and miR‐146b)...
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Original Article Source Type: research
More News: Arrhythmia | Boys | Brain | Cardiology | Cardiomyopathy | Cardiovascular | Dilated Cardiomyopathy | Electrocardiogram | Endocrinology | Girls | Heart | Heart Disease | Heart Failure | MRI Scan | Neurology | Pathology | Pediatrics | Study