Exosomes May Be the Potential New Direction of Research in Osteoarthritis Management.

Exosomes May Be the Potential New Direction of Research in Osteoarthritis Management. Biomed Res Int. 2019;2019:7695768 Authors: Ju C, Liu R, Zhang Y, Zhang F, Sun J, Lv XB, Zhang Z Abstract Osteoarthritis (OA) is a joint degenerative disease, which is prominent in the middle-aged and elderly population, often leading to repeated pain in the joints of patients and seriously affecting the life quality of patients. At present, the treatment of OA mainly depends on the surgery and drug treatment. Nevertheless, these treatments still face many problems, such as surgical safety, complications, and drug side effects. Exosomes can be secreted and released by multiple cell types and have lipid bilayer membranes and contain abundant biological molecules, including proteins, lipids, and nucleic acids. Moreover, exosomes play a critical role in local and distal intercellular and intracellular communication. In recent years, several studies have found that exosomes can regulate the progression of OA and have a potential efficacy for OA treatment. Thus, in this article, we summarize and review the relevant research of exosomes in OA and emphasize the importance of exosomes in the development of OA. PMID: 31781642 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research

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Source: Swiss Medical Weekly - Category: General Medicine Authors: Tags: Swiss Med Wkly Source Type: research
a Cruz Diane Liu Eduardo Bruera Palliative care is seeing cancer patients earlier in the disease trajectory with a multitude of chronic issues. Chronic non-malignant pain (CNMP) in cancer patients is under-studied. In this prospective study, we examined the prevalence and management of CNMP in cancer patients seen at our supportive care clinic for consultation. We systematically characterized each pain type with the Brief Pain Inventory (BPI) and documented current treatments. The attending physician made the pain diagnoses according to the International Association for the Study of Pain (IASP) task force classific...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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Source: Current Epidemiology Reports - Category: Epidemiology Source Type: research
Polzer H Abstract OBJECTIVE: Arthroscopic tibiotalocalcaneal arthrodesis (TTCA) aims at reconstructing a pain-free, orthograde, and functional limb with reduced invasiveness and lower complication rates compared to open arthrodesis. INDICATIONS: Combined osteoarthritis of the ankle and subtalar joint or hindfoot malalignment. CONTRAINDICATIONS: Osteomyelitis/deep soft tissue infections, talus necrosis, severe deformity of hindfoot or distal tibia, pronounced boney defect, indication for combined total ankle replacement and subtalar fusion. SURGICAL TECHNIQUE: Patient in supine position; arthros...
Source: Operative Orthopadie und Traumatologie - Category: Orthopaedics Authors: Tags: Oper Orthop Traumatol Source Type: research
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Source: Ochsner Journal - Category: General Medicine Tags: Ochsner J Source Type: research
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Source: Lions and Tigers and Bears - Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
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Source: Annals of Family Medicine - Category: Primary Care Authors: Tags: Ann Fam Med Source Type: research
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Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
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Source: Journal of Opioid Management - Category: Addiction Tags: J Opioid Manag Source Type: research
Osteoarthritis is a common and potentially debilitating condition. It’s a degenerative joint disease (often called the “wear-and-tear” type) in which the smooth lining of cartilage becomes thinned and uneven, exposing the bone beneath. Although osteoarthritis is tightly linked with aging, we now know there is more to it than age alone: genetics, weight, physical activity, and a number of other factors can conspire to make it more likely that someone will develop osteoarthritis while someone else won’t. Osteoarthritis is the primary reason that more than a million joints (mostly hips and knees) are r...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Arthritis Osteoarthritis Pain Management Source Type: blogs
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