Ellagic acid prolongs the lifespan of Drosophila melanogaster

AbstractWild-type Canton-S flies ofDrosophila melanogaster were treated with ellagic acid at 100  μM and 200 μM concentrations. Longevity assay showed male flies fed with 200 μM ellagic acid displayed longer mean lifespan and maximum lifespan than control flies. Female flies fed with 200 μM ellagic acid laid less number of eggs than control. The eclosion time was less in female flies fed with 200 μM ellagic acid. Ellagic acid fed female flies performed better than male flies and control flies for heat shock tolerance and starvation stress. Male flies treated with 100 μM ellagic acid recovered faster from cold shock compared with control flies. Male and female flies treated with e llagic acid displayed increased survival following exposure to 5% hydrogen peroxide. Gene expression studies displayed upregulated expressions of CAT, dFOXO, ATG1, and SOD2 in ellagic acid–treated male flies, and upregulated expressions of dFOXO, CAT, and SOD2 in ellagic acid–treated female flie s. Results from these studies show the pro-longevity effect of ellagic acid onDrosophila melanogaster.

Source: AGE - November 29, 2019 Category: Geriatrics Source Type: research