Modulation of growth hormone receptor-IGF1 axis by dietary protein in young ruminants.

Modulation of growth hormone receptor-IGF1 axis by dietary protein in young ruminants. Br J Nutr. 2019 Nov 28;:1-35 Authors: Firmenich CS, Schnepel N, Hansen K, Schmicke M, Muscher-Banse AS Abstract A reduced protein intake causes a decrease in insulin-like growth factor 1 (IGF1) concentrations and modulates calcium (Ca) homeostasis in young goats. The IGF1 is synthesised by the liver in response to stimulation by growth hormone (GH). Due to rumino-hepatic circulation of urea, ruminants are suitable for investigating the effects of a protein reduction despite sufficient energy intake. The present study aimed to investigate the impact of a protein reduced diet on the expression of components of the somatotropic axis. Male young goats were divided into two feeding groups receiving either a control diet (20% crude protein (CP)) or a reduced protein diet (9% CP). Blood concentrations of IGF1 and GH were measured and a 24-h GH secretion profile was compiled. Moreover, ionised Ca and insulin concentrations as well as mRNA and protein expression levels of hepatic proteins involved in GH signalling were quantified. Due to the protein reduced diet, concentrations of ionised Ca, insulin and IGF1 decreased significantly, whereas GH concentrations remained unchanged. Expression levels of the hepatic GH receptor (GHR) decreased during a protein reduction. The GHR expression was downregulated due to diminished insulin concentrations as both parame...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research