Use of topical Valsartan as a novel treatment of complicated leg ulcers.

Use of topical Valsartan as a novel treatment of complicated leg ulcers.
Br J Dermatol. 2019 Nov 28;:
Authors: Hirt PA, Lev-Tov H
Abstract
Venous leg ulcers (VLUs) are painful, recalcitrant to therapy and represent a significant burden on quality of patients' life and society (1). Therefore, innovative therapies are needed. Recently, the role of the renin-angiotensin system (RAS) in wound healing has been characterized in animal models (2). Given the availability and excellent safety profile of various RAS modulators, successful repurposing of these drugs to improve healing of chronic ulcers may prove useful in clinical settings.
PMID: 31778203 [PubMed - as supplied by publisher]

Source: The British Journal of Dermatology - November 27, 2019 Category: Dermatology Authors: Hirt PA, Lev-Tov H Tags: Br J Dermatol Source Type: research