Drosophila CTP synthase can form distinct substrate- and product-bound filaments

In this study, using negative staining and cryo-electron microscopy, we demonstrate that Drosophila CTPs, whether in substrate-bound or product-bound form, can form filaments. Our results challenge the previous model and indicate that substrate-bound and product-bound filaments can co-exist in the same species. We speculate that the ability to switch between active and inactive cytoophidia in the same cells provides an additional layer of metabolic regulation.
Source: Journal of Genetics and Genomics - Category: Genetics & Stem Cells Source Type: research
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