Immune reconstitution inflammatory syndrome in the lung in non-human immunodeficiency virus patients

ConclusionsThe diagnosis and management of IRIS in the lung in non-HIV patients should be investigated further, especially in the era of anti-TNF treatment.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research

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In this study we have genetically modified a serotype 1 strain (519/43), the first time that this has been achieved for this serotype, providing the methodology for a deeper understanding of its biology and pathogenicity. As proof of principle we constructed a defined pneumolysin mutant and showed that it lost its ability to lyse red blood cells. We also showed that when mice were infected intranasally with the mutant 519/43Δply there was no significant difference between the load of bacteria in lungs and blood when compared to the wild type 519/43. When mice were infected intraperitoneally there were significantly f...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
This study represents the first large scale attempt to gather a long period information on Q fever infection in Greece. The findings of the current study support the fact that Q fever is an important endemic zoonotic disease in Greece and needs increased awareness by clinical physicians and health care system.
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
(LOS ANGELES) — The U.S. has five confirmed cases of the new virus from China, all among people who traveled to the city at the center of the outbreak, health officials said Sunday. Two new cases were reported Sunday — one in Los Angeles County in California and the other in Maricopa County, Arizona. The latter case was someone with ties to Arizona State University who did not live in school housing, state health officials said. The three previously reported cases were a patient in Orange County, California; a man in his 30s in Washington state; and a woman in her 60s from Chicago. The virus can cause fever, c...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized California onetime Virus Source Type: news
Authors: Orsini D Abstract Poverty, high population density and unhealthy dwellings in Siena's historic district accounted for the spread of tuberculosis in its various forms between the mid-nineteenth century and the first three decades of the twentieth century. In this paper, the author relies on statistical data relating to a time span between 1898 and 1935 to discuss the high incidence of scrofula, or tuberculosis of the lymphatic glands, among Siena's infant population.The result is a description of the most important actions implemented at city level to prevent tuberculosis and to assist and treat sick childr...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Publication date: Available online 25 January 2020Source: The American Journal of SurgeryAuthor(s): Sharven Taghavi, Glenn Jones, Juan Duchesne, Patrick McGrew, Chrissy Guidry, Rebecca Schroll, Charles Harris, Reginald Nkansah, Tomas Jacome, Danielle TatumAbstractBackgroundThe association of procedure volume and improved outcomes has been established with infrequently performed elective operations. However, effect of trauma center volume on outcomes in emergency surgery has not been defined. We hypothesized that high volume centers (HVC) would provide better outcomes for operative major vascular injuries (MVI) than low vol...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Coronavirus expert Ralph Baric joins TWiV to explain the virology and epidemiology of the recent zoonotic outbreak spreading across China and overseas. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove,Rich Condit, Kathy Spindler Guest: Ralph Baric Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2020 WHO coronavirus sitreps CIDRAP article on coronavirus vaccines Phylogenetic analysis of 2019-nCoV ACE2 is 2019-nCoV receptor (bioRxiv) Visual explainer of Huanan market (SCMP) Clinical features of 2019-nCoV patients (Lancet...
Source: This Week in Virology - MP3 Edition - Category: Virology Authors: Source Type: podcasts
Publication date: Available online 25 January 2020Source: Journal of OrthopaedicsAuthor(s): Alex Gu, Frank R. Chen, Aaron Z. Chen, Safa C. Fassihi, Savyasachi Thakkar, Anthony S. Unger, Jiabin Liu, Peter K. Sculco, P. MichaelAbstractIntroductionThe purpose of this study is to investigate the relationship between preoperative hyponatremia and postoperative complications in aseptic revision hip and knee arthroplasty.MethodsAseptic revision arthroplasties from 2007-2016 were collected using a large, United States database. Patients were stratified into eunatremic and hyponatremic cohorts. Rates of complications were collected...
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
ConclusionEstimating the endotracheal tube insertion length in newborns using gestational age resulted in more correctly placed ET tube tips compared to weight.
Source: Journal of Neonatal Nursing - Category: Perinatology & Neonatology Source Type: research
In this study they also showed PTX3 localized in NETs formed after neutrophil activation (5). Proteomics analysis revealed that PTX3 forms complexes with two anti-microbial proteins [azurocidin (AZU1) and myeloperoxidase (MPO)] associated to NETs (30). More recently, PTX3 localization in NETs has been confirmed, and the colocalization with AZU1 and MPO has been defined more accurately (31). Further investigation will be needed to understand the involvement of PTX3 interaction with AZU1 and MPO in their antibacterial role during NET formation. Regulation of Complement Activation PTX3 interaction with microorganisms is not...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractThere is a lack of knowledge on the epidemiology of fungal infections worldwide because there are no reporting obligations. The aim of this study was to estimate the burden of fungal disease in Portugal as part of a global fungal burden project. Most published epidemiology papers reporting fungal infection rates from Portugal were identified. Where no data existed, specific populations at risk and fungal infection frequencies in those populations were used in order to estimate national incidence or prevalence, depending on the condition. An estimated 1,510,391 persons develop a skin or nail fungal infection each ye...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
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