Distress-Related Internalizing Symptoms Interact With Externalizing Symptoms to Predict Alcohol Problems in an Inpatient Adolescent Sample.

CONCLUSIONS: In this clinical sample, distress-related internalizing symptomatology was associated with risk for, and not protection against, hazardous AU, but only when accompanied by high externalizing symptoms. SCIENTIFIC SIGNIFICANCE: Findings suggest that whether or not internalizing symptoms operate synergistically with externalizing symptoms to predict hazardous AU depends on the subdomain of internalizing symptoms (distress vs fear) and perhaps the type of sample (ie, clinical vs community). (Am J Addict 2019:00:00-00). PMID: 31782592 [PubMed - as supplied by publisher]
Source: American Journal on Addictions - Category: Addiction Authors: Tags: Am J Addict Source Type: research

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Publication date: Available online 25 January 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): H. Saghafi, P. Benington, A. AyoubAbstractThe aim of this study was to compare the impact that the orthodontics-first approach and the surgery-first approach have on quality of life, anxiety, and depression in patients treated for dentofacial deformities. Data were collected on 32 patients (aged 17–47 years) who were all treated at a single multidisciplinary orthognathic clinic. They completed a 22-item Orthognathic Quality of Life Questionnaire (OQLQ), a seven-item Generalised Anxiety Disorder (GAD-7...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: Available online 25 January 2020Source: Pharmacology &TherapeuticsAuthor(s): Yun-Feng LiAbstractMajor depressive disorder has become a global public health problem of serious concern. Most of the clinical antidepressants are developed under the classic “monoamine hypothesis (strategy)”. These drugs generally have such deficiencies including slow onset and limited efficiency, cognitive impairment and suicidal tendency. Therefore, it is the direction to break through the classic monoamine strategy framework for developing antidepressants that have fast-acting, lower side effects, and cogniti...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
ConclusionsThe results suggested that KXS exerted antidepressant effects by regulating the signaling pathways involved in lipid metabolism disorders. The lipid metabolites might be potential biomarkers of depression and possible targets for KXS-based treatment of depression.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
This study aims to explore the relationship between miR-195 and CD40 and its effect on Th17/Treg balance in rats with non-alcoholic fatty liver disease (NAFLD).MethodsWe established rat models of NAFLD and made seven groups, Normal group (without modeling), Model group (model rats), NC group (model rats injected with negative control vector), miR-195 OE group (model rats injected with miR-195 mimic), anti-miR-195 group (model rats injected with miR-195 inhibitor), Si-CD40 group (model rats injected with CD40 silencing vector), and anti-miR-195+Si-CD40 group (model rats injected with miR-195 inhibitor and CD40 silencing vec...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Source: Addiction Research and Theory - Category: Addiction Authors: Source Type: research
The Centers for Disease Control and Prevention (CDC) is concealing and suppressing information on the number one cause of severe, vaping-related health harm to youths in order to deceive the public into thinking that e-cigarettes are at the top of the list.In fact, the number one cause of severe, vaping-related health damage to youths is not electronic cigarettes, although you would not know that from reading the CDC's literature on youth vaping.The Rest of the StoryThe chief cause of substantial health harms to youth from vaping is actually not e-cigarettes. It is marijuana or THC vaping.The hundreds of youth who have bec...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - Category: Addiction Source Type: blogs
Publication date: Available online 25 January 2020Source: Materials LettersAuthor(s): Nan He, Xinwei Liu, Fei Gao, Qiangqiang Zhang, Miaocheng Zhang, Yu Wang, Xinyi Shen, Xiang Wan, Xiaojuan Lian, Ertao Hu, Lin He, Jianguang Xu, Yi TongAbstractAs the emerging device for neuromorphic applications, memristive device is arguable regarded as the most promising candidate to emulate biological synapse due to its specific analog behaviors and various plasticities. Nevertheless, the stability of memristive device remains an extreme challenge limiting its practical applications. In this work, two-dimensional (2D) material MXene is ...
Source: Materials Letters - Category: Materials Science Source Type: research
Source: Journal of Mental Health - Category: Psychiatry Authors: Source Type: research
In this study, we examined the clinical and psychosocial characteristics of youth at familial and clinical high risk (HR) for BD, and compared these characteristics to those of youth with BD I and II. Both groups were recruited based on current, active mood symptoms from separate randomized trials of family therapy. A total of 127 HR youth were evaluated: 52 (40.9%) were diagnosed with BD-NOS and 75 (59.1%) were diagnosed with MDD. Compared to adolescents with BD I and II (n=145), HR youth had higher rates of anxiety disorders, and comparable rates of attention-deficit/hyperactivity disorder and oppositional defiant disord...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
CONCLUSIONS: Our findings suggest that people who die by suicide while under the influence of alcohol are more likely to be under acute stress (e.g. separation) and not have earlier psychiatric conditions, except substance use. This highlights the importance of more strict alcohol policies, but also the need to improve substance use treatment. PMID: 31973775 [PubMed - in process]
Source: Epidemiology and Psychiatric Sciences - Category: Psychiatry Tags: Epidemiol Psychiatr Sci Source Type: research
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