Comparing different domains of analysis for the characterisation of N-Glycans on monoclonal antibodies

In this study, ten different analytical workflows for N-glycan analysis were compared on four therapeutic monoclonal antibodies. While observing good comparability between the quantitative results generated, it was possible to appreciate the advantages and disadvantages of each technique and to summarise all the observations to guide the choice of the most appropriate analytical workflow according to application and the desired depth of data generated.Graphical abstract
Source: Journal of Pharmaceutical Analysis - Category: Drugs & Pharmacology Source Type: research